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Preface / David Naor, Pierre De Meyts | ||||||
Definition of Signals for Neuronal Differentiation / Axel Obermeier, Ralph A. Bradshaw, Klaus Seedorf, Axel Choidas, Joseph Schlessinger, Axel Ullrich | 1 | |||||
Structure and Catalytic Properties of Protein Tyrosine Phosphatases / Jack E. Dixon | 18 | |||||
The G Protein-coupled Receptor Family and One of Its Members, the TSH Receptor / G. Vassart, F. Desarnaud, L. Duprez, D. Eggerickx, O. Labbe, F. Libert, C. Mollereau, J. Parma, R. Paschke, M. Tonacchera, P. Vanderhaeghen, J. Van Sande, J. Dumont, M. Parmentier | 23 | |||||
Inositol Trisphosphate and Calcium Signaling / Michael J. Berridge | 31 | |||||
Interaction of Signaling and Trafficking Proteins with the Carboxyterminus of the Epidermal Growth Factor Receptor / Graham Carpenter, Concepcio Soler, Josep Baulida, Laura Beguinot, Alexander Sorkin | 44 | |||||
Control of T-Cell Development by the Pre-T and [actual symbol not reproducible] T-Cell Receptor / Harald von Boehmer | 52 | |||||
T-Cell Recognition of Antigen: A Process Controlled by Transient Intermolecular Interactions / J. Jay Boniface, Mark M. Davis | 62 | |||||
Receptors That Regulate T-Cell Susceptibility to Apoptotic Cell Death / Lawrence H. Boise, Andy J. Minn, Craig B. Thompson | 70 | |||||
Signaling Difference between Class IgM and IgD Antigen Receptors / Kwang-Myong Kim, Michael Reth | 81 | |||||
Interaction of p56[superscript lck] with CD4 in the Yeast Two-hybrid System / Kerry S. Campbell, Annie Buder, Ulrich Deuschle | 89 | |||||
Induction of Terminal Differentiation of Promyelocytic HL-60 Leukemic Cells Implanted with Lymphocyte Receptors and Stimulated with Various Lymphocyte Stimulators / Irit Altboum, Israel Zan-Bar | 93 | |||||
Independent Signaling for Growth Arrest and Apoptosis by Ig[alpha] and Ig[beta] Subunits of the B-Cell Antigen Receptor Complex / Xiao-Rui Yao, David W. Scott | 96 | |||||
The Kinase-dependent Function of Lck in T-Cell Activation Requires and Intact Site for Tyrosine Autophosphorylation / Hua Xu, Dan R. Littman | 99 | |||||
Coreceptors and Adapter Proteins in T-Cell Signaling / K. S. Ravichandran, J. C. Pratt, S. Sawasdikosol, H. Y. Irie, S. J. Burakoff | 117 | |||||
Symmetry of the Activation of Cyclin-dependent Kinases in Mitogen and Growth Factor-stimulated T Lymphocytes / Jaime F. Modiano, Joanne Domenico, Agota Szepesi, Naohiro Terada, Joseph J. Lucas, Erwin W. Gelfand | 134 | |||||
Molecular and Genetic Insights into T-Cell Antigen Receptor Signaling / Arthur Weiss, Theresa Kadlecek, Makio Iwashima, Andrew Chan, Nicolai van Oers | 149 | |||||
Signal Transduction Mediated by the T-Cell Antigen Receptor / Lawrence E. Samelson, Jerald A. Donovan, Noah Isakov, Yasuo Ota, Ronald L. Wange | 157 | |||||
Genetic Dissection of the Transducing Subunits of the T-Cell Antigen Receptor / Bernard Malissen, Grace Ku, Mirjam Hermans, Eric Vivier, Marie Malissen | 173 | |||||
The Cyclosporin-sensitive Transcription Factor NFATp Is Expressed in Several Classes of Cells in the Immune System / Don Z. Wang, Patricia G. McCaffrey, Anjana Rao | 182 | |||||
Signal Transduction by the B-Cell Antigen Receptor / Anthony L. DeFranco, James D. Richards, Jonathan H. Blum, Tracy L. Stevens, Debbie A. Law, Vivien W.-F. Chan, Sandip K. Datta, Shaun P. Foy, Sharon L. Hourihane, Michael R. Gold, Linda Matsuuchi | 195 | |||||
Interaction of Shc with Grb2 Regulates the Grb2 Association with mSOS / K. S. Ravichandran, U. Lorenz, S. E. Shoelson, S. J. Burakoff | 202 | |||||
A 115 KDa Tyrosine Phosphorylated Protein Associates with Grb-2 in Activated Jurkat Cells / Herman Meisner, Michael P. Czech | 204 | |||||
Csk Associates with the TCR [actual symbol not reproducible] Chains through Its SH2 Domain / Thorunn Rafnar, Jonathan P. Schneck, Mary E. Brummet, David G. Marsh, Branimir Catipovic | 206 | |||||
Fc Receptor Stimulation of PI 3-Kinase in NK Cells Is Associated with Protein Kinase C-independent Granule Release and Cell-mediated Cytotoxicity / Joy D. Bonnema, Larry M. Karnitz, Renee A. Schoon, Robert T. Abraham, Paul J. Leibson | 209 | |||||
Potentiation of B-Cell Antigen Receptor-mediated Signal Transduction by the Heterologous src Family Protein Tyrosine Kinase, src / Jiejian Lin, Anne L. Burkhardt, Joseph B. Bolen, Louis B. Justement | 214 | |||||
Regulation of Human Natural Killer-Cell Lytic Activity by Serine/Threonine Phosphatases and Kinases / Anil Bajpai, Zacharie Brahmi | 216 | |||||
Mechanisms of Enhanced Nuclear Translocation of the Transcription Factors c-Rel and NF-kB by CD28 Costimulation in Human T Lymphocytes / Jenn-Haung Lai, Gyorgyi Horvath, Yongqin Li, Tse-Hua Tan | 220 | |||||
Cytokine Signal Transduction through a Homo- or Heterodimer of gp130 / Tadamitsu Kishimoto, Takashi Tanaka, Kanji Yoshida, Shizuo Akira, Tetsuya Taga | 224 | |||||
IL-2 Signaling Involves Recruitment and Activation of Multiple Protein Tyrosine Kinases by the IL-2 Receptor / Tadatsugu Taniguchi, Tadaaki Miyazaki, Yasuhiro Minami, Atsuo Kawahara, Hodaka Fujii, Yoko Nakagawa, Masanori Hatakeyama, Zhao-Jun Liu | 235 | |||||
Costimulation Requirement for AP-1 and NF-kB Transcription Factor Activation in T Cells / Steffen Jung, Avraham Yaron, Irit Alkalay, Ada Hatzubai, Ayelet Avraham, Yinon Ben-Neriah | 245 | |||||
Structural Aspects of Cytokine/Receptor Interactions / Nicos A. Nicola | 253 | |||||
Cell Growth Signal Transduction Is Quantal / Kendall A. Smith | 263 | |||||
TNF[alpha] Is an Effective Therapeutic Target for Rheumatoid Arthritis / Marc Feldmann, Fionula M. Brennan, Michael J. Elliott, Richard O. Williams, Ravinder N. Maini | 272 | |||||
Investigation of Ligand Binding to Members of the Cytokine Receptor Family within a Microbial System / K. H. Young, B. A. Ozenberger | 279 | |||||
The Proline-rich Motif Is Necessary but Not Sufficient for Prolactin Receptor Signal Transduction / Kevin D. O'Neal, Li-Yuan Yu-Lee, William T. Shearer | 282 | |||||
Activation of Multiple Protein Kinases by Interleukin-1 / J. E. Dunford, N. R. Corbett, C. L. Varley, C. H. Dawson, B. L. Brown, P. R. M. Dobson | 285 | |||||
IL-8 Signal Transduction in Human Neutrophils / Cindy Knall, G. Scott Worthen, Anne Mette Buhl, Gary L. Johnson | 288 | |||||
IL-8 Induces Calcium Mobilization in Interleukin-2-Activated Natural Killer Cells Independently of Inositol 1,4,5 Trisphosphate / Ala Al-Aoukaty, Adel Giaid, Azzam A. Maghazachi | 292 | |||||
Interleukin-11 Induces Tyrosine Phosphorylation, and c-jun and c-fos mRNA Expression in Human K562 and U937 Cells / Samuel E. Adunyah, Glendora C. Spencer, Roland S. Cooper, Juan A. Rivero, Karamba Ceesay | 296 | |||||
Analysis of the Interaction between Two TGF-[beta]-binding Proteins and Three TGF-[beta] Isoforms Using Surface Plasmon Resonance / M. D. O'Connor-McCourt, P. Segarini, S. Grothe, M. L.-S. Tsang, J. A. Weatherbee | 300 | |||||
The Stress-activated Protein Kinases: A Novel ERK Subfamily Responsive to Cellular Stress and Inflammatory Cytokines / John M. Kyriakis, James R. Woodgett, Joseph Avruch | 303 | |||||
Protein Serine/Threonine Kinases of the MAPK Cascade / J. D. Graves, J. S. Campbell, E. G. Krebs | 320 | |||||
Structural Aspects of Receptor Dimerization: c-Kit as an Example / Janna M. Blechman, Yosef Yarden | 344 | |||||
Signal Transduction Interception as a Novel Approach to Disease Management / Alexander Levitzki | 363 | |||||
Common and Distinct Elements in Insulin and PDGF Signaling / Martin G. Myers, Jr., Bentley Cheatham, Tracey L. Fisher, Bozena R. Jachna, C. Ronald Kahn, Jonathan M. Backer, Morris F. White | 369 | |||||
Mechanisms of Insulin and IGF-I Receptor Activation and Signal Transduction Specificity: Receptor Dimer Cross-linking, Bell-shaped Curves, and Sustained versus Transient Signaling / Pierre De Meyts, Birgitte Urso, Claus T. Christoffersen, Ronald M. Shymko | 388 | |||||
The Role of the Insulin-like Growth Factor-I Receptor in Cancer / D. LeRoith, H. Werner, S. Neuenschwander, T. Kalebic, L. J. Helman | 402 | |||||
Mitogenic Potential of Insulin on Lymphoma Cells Lacking IGF-1 Receptor / Dvorah Ish-Shalom, Guri Tzivion, Claus T. Christoffersen, Birgitte Urso, Pierre De Meyts, David Naor | 409 | |||||
Platelet-derived Growth Factor: Distinct Signal Transduction Pathways Associated with Migration versus Proliferation / Karin E. Bornfeldt, Elaine W. Raines, Lee M. Graves, Michael P. Skinner, Edwin G. Krebs, Russell Ross | 416 | |||||
Thrombin and Its Receptor in Growth Control / Ellen Van Obberghen-Schilling, Valerie Vouret-Craviari, Yao-Hui Chen, Dominique Grall, Jean-Claude Chambard, Jacques Pouyssegur | 431 | |||||
Structural and Functional Properties of the TRK Family of Neurotrophin Receptors / Mariano Barbacid | 442 | |||||
Protein Kinase C Mediates Short- and Long-term Effects on Receptor Tyrosine Kinases: Regulation of Tyrosine Phosphorylation and Degradation / Klaus Seedorf, Mark Sherman, Axel Ullrich | 459 | |||||
Flag-Insulin Receptor Mutants / H. Joseph Goren | 463 | |||||
Localization of Specific Amino Acids Contributing to Insulin Specificity of the Insulin Receptor / Asser S. Andersen, Finn C. Wiberg, Thomas Kjeldsen | 466 | |||||
The Acute Insulin-like Effects of Growth Hormone in Primary Adipocyte-signaling Mechanisms / Hans Tornqvist, Martin Ridderstrale, Hans Eriksson, Eva Degerman | 469 | |||||
Regulatory Interaction between Calmodulin and the Epidermal Growth Factor Receptor / Alberto Benguria, Jose Martin-Nieto, Gustavo Benaim, Antonio Villalobo | 472 | |||||
Phosphorylation of Connexin-32 by the Epidermal Growth Factor Receptor Tyrosine Kinase / Juan Antonio Diez, Maribel Elvira, Antonio Villalobo | 477 | |||||
Molecular Dissection of the Growth Hormone Receptor: Identification of Distinct Cytoplasmic Domains Corresponding to Different Signaling Pathways / J. H. Nielsen, N. Billestrup, G. Allevato, A. Moldrup, E. D. Petersen, J. Amstrup, J. A. Hansen, C. Svensson | 481 | |||||
Endothelin Stimulates MAP Kinase Activity and Protein Synthesis in Isolated Adult Feline Cardiac Myocytes / Linda G. Jones, Katrina C. Gause, Kathryn E. Meier | 484 | |||||
Index of Contributors | 487 |
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