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Contributors | ||||||
Preface | ||||||
Cumulative Listing of Volumes in Series | ||||||
Ch. 1 | Chirality and Drug Hazards / Hassan Y. Aboul-Enein, Laila I. Abou Basha | 1 | ||||
Ch. 2 | Stereochemistry in the Drug Development Process: Role of Chirality as a Determinant of Drug Action, Metabolism, and Toxicity / Thomas A. Baillie, Kathleen M. Schultz | 21 | ||||
Ch. 3 | Stereochemical Aspects of Drug Metabolism / Jonathan P. Mason, Andrew J. Hutt | 45 | ||||
Ch. 4 | Some Examples for Stereoselective Biotransformation of Drugs / Gottfried Blaschke | 107 | ||||
Ch. 5 | Kinetics of Reactive Phase II Metabolites: Stereochemical Aspects of Formation of Epimeric Acyl Glucoronides and their Reactivity / Hildegard Spahn-Langguth, Leslie Z. Benet, Parnian Zia-Amirhosseini [et al.] | 125 | ||||
Ch. 6 | Studies on the Stereoselectivity of the Biologically Important Metabolism of Alkene-Alkene Oxide (Oxirane)-Alkanediol / Dorothee Wistuba | 173 | ||||
Ch. 7 | Chiral Barbiturates: Synthesis, Chromatographic Resolutions, and Biological Activity / Jacek Bojarski | 201 | ||||
Ch. 8 | Ethambutol and Tuberculosis, a Neglected and Confused Chiral Puzzle / Bernard Blessington | 235 | ||||
Ch. 9 | Stereogenic Elements of Pharmaceutical Compounds: Some Aspects on Isomerism, Resolution, and Stereochemical Integrity / Stig G. Allen Mark | 263 | ||||
Ch. 10 | The Importance of Chiral Separations of Pharmaceuticals / Sut Ahuja | 287 | ||||
Ch. 11 | Separation of Optically Active Pharmaceuticals Using Capillary Electrophoresis / Timothy J. Ward, Karen D. Ward | 317 | ||||
Ch. 12 | Chiral Recognition Mechanism of Polysaccharides Chiral Stationary Phases / Eji Yashima, Yoshio Okamoto | 345 | ||||
Ch. 13 | Micelle-Mediated Capillary Electrophoretic Separation of Enantiomeric Compounds / Michael E. Swartz, Phyllis R. Brown | 377 | ||||
Ch. 14 | Unified Enantioselective Chromatography Involving Chirasil-Dex / Volker Schurig, Sabine Mayer, Martin Jung [et al.] | 401 | ||||
Ch. 15 | Derivatized Cyclodextrins as Chiral Gas Chromatographic Stationary Phases and their Potential Applications in the Pharmaceutical Industry / Weiyong Li, Thomas M. Rossi | 415 | ||||
Ch. 16 | Chiral Derivatization Reagents in the Bioanalysis of Optically Active Drugs with Chromophore-Based Detection / Ralf Buschges, Hassan Y. Aboul-Enein, Eric Martin [et al.] | 437 | ||||
Ch. 17 | Circular Dichroism Spectroscopy in the Analysis of Chiral Drugs / Piera Salvadori, Carlo Rosini, Carlo Bertucci | 493 | ||||
Ch. 18 | Circular Dichroism in the Study of Stereoselective Binding of Drugs to Serum Proteins / Carlo Bertucci, Piero Salvadori, Enrico Domenici | 521 | ||||
Ch. 19 | Current Regulatory Guidelines of Stereoisomeric Drugs: North American, European, and Japanese Point of View / Sylvie Laganiere | 545 | ||||
Ch. 20 | Enantioselective Analysis and the Regulation of Chiral Drugs / Michael Gross | 565 | ||||
Ch. 21 | First Pass Phenomena: Sources of Stereoselectivities and Variabilities of Concentration-Time Profiles After Oral Dosage / Hildegard Spahn-Langguth, Leslie Z. Benet, Werner Mohrke [et al.] | 573 | ||||
Ch. 22 | Gastrointestinal Transport Processes: Potentials for Stereoselectivities at Substrate-Specific and Nonspecific Epithelial Transport Systems / Peter Langguth, Gordon L. Amidon, Elke Lipka [et al.] | 611 | ||||
Ch. 23 | Preparation of Drug Enantiomers by Chromatographic Resolution on Chiral Stationary Phases / Eric Francotte | 633 |
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