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Title The impact of stereochemistry on drug development and use / [edited by] Hassan Y. Aboul-Enein and Irving W. Wainer
Imprint New York : J. Wiley, [1997]
©1997

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CWRUOhio State UU of Toledo
Ohio DepositoryOhio UUrsuline College

LibraryLocationCall Number/Serial HoldingsStatus
CWRU KSL Stacks 3rd Floor RS429.I48 1997 AVAILABLE
Ohio Depository Ohio Depository NorthWest : Bowling Green State University RS429.I48 1997 TEMP UNAVAIL
Ohio State U Book Depository RS429 .I48 1997 AVAILABLE
Ohio U Alden 7th Floor RS429 .I48 1997 AVAILABLE
U of Toledo CARLSON General (4th fl) RS429 .I48 1997 AVAILABLE
Ursuline College URSULINE SECOND FLOOR RS 429 .I48 1997 AVAILABLE

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Contents

 Contributors 
 Preface 
 Cumulative Listing of Volumes in Series 
Ch. 1Chirality and Drug Hazards / Hassan Y. Aboul-Enein, Laila I. Abou Basha1
Ch. 2Stereochemistry in the Drug Development Process: Role of Chirality as a Determinant of Drug Action, Metabolism, and Toxicity / Thomas A. Baillie, Kathleen M. Schultz21
Ch. 3Stereochemical Aspects of Drug Metabolism / Jonathan P. Mason, Andrew J. Hutt45
Ch. 4Some Examples for Stereoselective Biotransformation of Drugs / Gottfried Blaschke107
Ch. 5Kinetics of Reactive Phase II Metabolites: Stereochemical Aspects of Formation of Epimeric Acyl Glucoronides and their Reactivity / Hildegard Spahn-Langguth, Leslie Z. Benet, Parnian Zia-Amirhosseini [et al.]125
Ch. 6Studies on the Stereoselectivity of the Biologically Important Metabolism of Alkene-Alkene Oxide (Oxirane)-Alkanediol / Dorothee Wistuba173
Ch. 7Chiral Barbiturates: Synthesis, Chromatographic Resolutions, and Biological Activity / Jacek Bojarski201
Ch. 8Ethambutol and Tuberculosis, a Neglected and Confused Chiral Puzzle / Bernard Blessington235
Ch. 9Stereogenic Elements of Pharmaceutical Compounds: Some Aspects on Isomerism, Resolution, and Stereochemical Integrity / Stig G. Allen Mark263
Ch. 10The Importance of Chiral Separations of Pharmaceuticals / Sut Ahuja287
Ch. 11Separation of Optically Active Pharmaceuticals Using Capillary Electrophoresis / Timothy J. Ward, Karen D. Ward317
Ch. 12Chiral Recognition Mechanism of Polysaccharides Chiral Stationary Phases / Eji Yashima, Yoshio Okamoto345
Ch. 13Micelle-Mediated Capillary Electrophoretic Separation of Enantiomeric Compounds / Michael E. Swartz, Phyllis R. Brown377
Ch. 14Unified Enantioselective Chromatography Involving Chirasil-Dex / Volker Schurig, Sabine Mayer, Martin Jung [et al.]401
Ch. 15Derivatized Cyclodextrins as Chiral Gas Chromatographic Stationary Phases and their Potential Applications in the Pharmaceutical Industry / Weiyong Li, Thomas M. Rossi415
Ch. 16Chiral Derivatization Reagents in the Bioanalysis of Optically Active Drugs with Chromophore-Based Detection / Ralf Buschges, Hassan Y. Aboul-Enein, Eric Martin [et al.]437
Ch. 17Circular Dichroism Spectroscopy in the Analysis of Chiral Drugs / Piera Salvadori, Carlo Rosini, Carlo Bertucci493
Ch. 18Circular Dichroism in the Study of Stereoselective Binding of Drugs to Serum Proteins / Carlo Bertucci, Piero Salvadori, Enrico Domenici521
Ch. 19Current Regulatory Guidelines of Stereoisomeric Drugs: North American, European, and Japanese Point of View / Sylvie Laganiere545
Ch. 20Enantioselective Analysis and the Regulation of Chiral Drugs / Michael Gross565
Ch. 21First Pass Phenomena: Sources of Stereoselectivities and Variabilities of Concentration-Time Profiles After Oral Dosage / Hildegard Spahn-Langguth, Leslie Z. Benet, Werner Mohrke [et al.]573
Ch. 22Gastrointestinal Transport Processes: Potentials for Stereoselectivities at Substrate-Specific and Nonspecific Epithelial Transport Systems / Peter Langguth, Gordon L. Amidon, Elke Lipka [et al.]611
Ch. 23Preparation of Drug Enantiomers by Chromatographic Resolution on Chiral Stationary Phases / Eric Francotte633
Description xxvii, 695 pages : illustrations ; 24 cm
Series Chemical analysis ; v. 142
Note Series label on spine corrected
Includes bibliographical references and index
Contents Chirality and drug hazards / Hassan Y. Aboul-Enein and Laila I. Abou Basha -- Stereochemistry in the drug development process : role of chirality as a determinant of drug action, metabolism, and toxicity / Thomas A. Baillie and Kathleen M. Schultz -- Stereochemical aspects of drug metabolism / Jonathan P. Mason and Andrew J. Hutt -- Some examples for stereoselective biotransformation of drugs / Gottfried Blaschke -- Kinetics of reactive phase II metabolites : stereochemical aspects of formation of epimeric acyl glucuronides and their reactivity / Hildegard Spahn-Langguth ... [and others] -- Studies on the stereoselectivity of the biologically important metabolism of alkene-alkene oxide (oxirane)-alkanediol / Dorothee Wistuba -- Chiral barbiturates : synthesis, chromatographic resolutions, and biological activity / Jacek Bojarski -- Ethambutol and tuerculosis, a neglected and confused chiral puzzle / Bernard Blessington -- Stereogenic elements of pharmaceutical compounds : some aspects on isomerism, resolution, and stereochemical integrity / Stig G. Allen Mark -- The importance of chiral seperations in pharmaceuticals / Sut Ahuja -- Seperation of optically active pharmaceuticals using capillary electrophoresis / Timothy J. Ward and Karen D. Ward -- Chiral recognition mechanism of polysaccharides chiral stationary phases / Eji Yashima and Yoshio Okamoto -- Michelle-mediated capillary electrophoretic separation of enantomeric compounds / Michael E. Swartz and Phyllis R. Brown -- Unified enantioselective chromatography involving chirasil-dex / Volker Schurig ... [and others] -- Derivatized cyclodextrins as chiral gas chromatographic stationary phases and their potential applications in the pharmaceutical industry / Weiyong Li and Thomas M. Rossi -- Chiral derivatization reagents in the bioanalysis of optically active drugs with chromophore-based detection / Ralf Büschges ... [and others] -- Circular dichroism spectroscopy in the analysis of chiral drugs / Piera Salvadori, Carlo Rosini, and Carlo Bertucci -- Circular Dichroism in the study of stereoselective binding of drugs to serum proteins / Carlo Bertucci, Piero Salvadori, and Enrico Domenici -- Current regulatory guidelines of stereoisomeric drugs : North American, European, and Japanese point of view / Sylvie Laganiére -- Enantioselective analysis and the regulation of chiral drugs / Michael Gross -- First pass phenomena : sources of stereoselectives and variabilities of concentration-time profiles after oral dosage / Hildegard Spahn-Langguth ... [and others] -- Gastrointestinal transport processes : potentials for stereoselectivities at substrate-specific and nonspecific epithelial transport systems / Peter Langguth -- Preparation of drug enantiomers by chromatographic resolution on chiral stationary phases / Eric Francotte
Subjects Chiral drugs
Alt Name Aboul-Enein, Hassan Y
Wainer, Irving W
Dewey No 615/.7 20
LC NO RS429 .I48 1997
OCLC # 35262289
ISBN 0471596442
LCCN 96033491

Bookmark this record as <https://olc1.ohiolink.edu:443/record=b17694769>


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