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| Contributors | ||||||
| ABC Transporters: an Introduction and Overview / Christopher F. Higgins, Kenneth J. Linton | ||||||
| Ch. 1 | Phylogenetic and Functional Classification of ABC (ATP-binding Cassette) Systems / Elie Dassa | 3 | ||||
| Ch. 2 | Membrane Topology of the Human ABC Transporter Proteins / Andras Varadi, Gabor E. Tusnady, Balazs Sarkadi | 37 | ||||
| Ch. 3 | Human and Drosophila ABC Proteins / Michael Dean, Andrey Rzhetsky, Rando Allikmets | 47 | ||||
| Ch. 4 | Structure of ABC Transporters / Kenneth J. Linton, Mark F. Rosenberg, Ian D. Kerr, Christopher F. Higgins | 65 | ||||
| Ch. 5 | Substrate-binding Sites in ABC Transporters / Hendrik W. van Veen, Richard Callaghan | 81 | ||||
| Ch. 6 | Probing of Conformational Changes, Catalytic Cycle and ABC Transporter Function / Frances J. Sharom | 107 | ||||
| Ch. 7 | X-ray Structure of an Intact ABC Transporter, MsbA / Christopher B. Roth, Geoffrey A. Chang | 135 | ||||
| Ch. 8 | Introduction to Bacterial ABC Proteins / I. Barry Holland | 149 | ||||
| Ch. 9 | Import and Solutes by ABC Transporters - the Maltose and Other Systems / Erwin Schneider | 157 | ||||
| Ch. 10 | Crystal Structures of Periplasmic Solute-binding Proteins in ABC Transport Complexes Illuminate Their Function / Anthony J. Wilkinson, Koen H. G. Verschueren | 187 | ||||
| Ch. 11 | Bacterial ABC Transporters Involved in Protein Translocation / I. Barry Holland, Houssain Benabdelhak, Joanne Young, Andrea de Lima Pimenta, Lutz Schmitt, Mark A. Blight | 209 | ||||
| Ch. 12 | Bacterial Multidrug Resistance Mediated by ABC Transporters / Gerrit J. Poelarends, Catherine Vigano, Jean-Marie Ruysschaert, Wil N. Konings | 243 | ||||
| Ch. 13 | Structure and Function of Osmoregulated ABC Transporters / Bert Poolman, Tiemen van der Heide | 263 | ||||
| Ch. 14 | Inventory and Evolution of Fungal ABC Protein Genes / Christoph Schuller, Bettina E. Bauer, Karl Kuchler | 279 | ||||
| Ch. 15 | Fungal ABC Proteins in Clinical Drug Resistance and Cellular Detoxification / Bettina E. Bauer, Christoph Schuller, Karl Kuchler | 295 | ||||
| Ch. 16 | Drug Resistance Mediated by ABC Transporters in Parasites of Humans / Marc Ouellette, Danielle Legare | 317 | ||||
| Ch. 17 | The Plant ABC Transporter Superfamily: the Functions of a Few and Identities of Many / Philip A. Rea, Rocio Sanchez-Fernandez, Sixue Chen, Mingsheng Peng, Markus Klein, Markus Geisler, Enrico Martinoia | 335 | ||||
| Ch. 18 | Solving the Problem of Multidrug Resistance: ABC Transporters in Clinical Oncology / Susan E. Bates | 359 | ||||
| Ch. 19 | Multidrug Resistance Protein 1 (ABCC1) / Roger G. Deeley, Susan P. C. Cole | 393 | ||||
| Ch. 20 | MRP2, the Apical Export Pump for Anionic Conjugates / Jorg Konig, Anne T. Nies, Yunhai Cui, Dietrich Keppler | 423 | ||||
| Ch. 21 | The Multidrug Resistance Proteins 3-7 / Piet Borst, Glen Reid, Tohru Saeki, Peter Wielinga, Noam Zelcer | 445 | ||||
| Ch. 22 | Lipid Transport by ABC Transporters / Piet Borst, Gerrit van Meer, Ronald Oude Elferink | 461 | ||||
| Ch. 23 | Role of ABCA1 in Cell Turnover and Lipid Homeostasis / Giovanna Chimini, Olivier Chambenoit, Christopher Fielding | 479 | ||||
| Ch. 24 | Peroxisomal ABC Transporters / Shlomo Almashanu, David Valle | 497 | ||||
| Ch. 25 | ABC Transporters in Mitochondria / Roland Lill, Gyula Kispal | 515 | ||||
| Ch. 26 | The Transporter Associated with Antigen Processing (TAP): a Peptide Transport and Loading Complex Essential for Cellular Immune Response / Brigitte Lankat-Buttgereit, Robert Tampe | 533 | ||||
| Ch. 27 | The Sulfonylurea Receptor: an ABCC Transporter that Acts as an Ion Channel Regulator / Michinori Matsuo, Kazumitsu Ueda, Timothy Ryder, Frances Ashcroft | 551 | ||||
| Ch. 28 | ABC Transporters and Human Eye Disease / Rando Allikmets | 577 | ||||
| Ch. 29 | The Cystic Fibrosis Transmembrane Conductance Regulator (ABCC7) / John W. Hanrahan, Martina Gentzsch, John R. Riordan | 589 | ||||
| Ch. 30 | ABC Proteins, the Fascination, the Politics, the Potential for Applications for Improving Human Health / I. Barry Holland | 619 | ||||
| Index | 625 | |||||
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