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Review
Current global status of male reproductive health
Christopher J De Jonge and others
BACKGROUND The widespread interest in male reproductive health (MRH), fueled by emerging evidence, such as the global decline in sperm counts, has intensified concerns about the status of MRH. Consequently, there is a pressing requirement for a strategic, systematic approach to identify critical ...
Original Article
The risk of type 1 diabetes in children born after ART: a nordic cohort study from the CoNARTaS group
Frederik Kyhl and others
STUDY QUESTION Do children born after ART have a higher risk of developing type 1 diabetes (DM1) than children conceived without ART? SUMMARY ANSWER The risk of DM1 was similar for children conceived with and without ART, and there were no clear differences in risk according to method of fertility ...
Original Article
Effects of Tcte1 knockout on energy chain transportation and spermatogenesis: implications for male infertility
Marta Olszewska and others
STUDY QUESTION Is Tcte1 mutation causative for male infertility? SUMMARY ANSWER Our collected data underline the complex and devastating effect of the single-gene mutation on the testicular molecular network, leading to male reproductive failure. WHAT IS KNOWN ALREADY Recent data have revealed ...
Original Article
Pre-treatment with oral contraceptive pills in women with PCOS scheduled for IVF: a randomized clinical trial
Gao Jun and others
STUDY QUESTION What is the effect of pre-treatment with oral contraceptive pills (OCP) on oocyte and embryo quality and pregnancy rates in women with PCOS scheduled for IVF/ICSI cycles? SUMMARY ANSWER In women with PCOS who underwent a first or second IVF/ICSI cycle with a GnRH antagonist protocol ...
Original Article
Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy
Nicolas Jovanovic and others
STUDY QUESTION Is exposure to environmental chemicals associated with modification of placental morphology and function? SUMMARY ANSWER Phthalates, a class of ubiquitous chemicals, showed an association with altered placental weight, placental vascular resistance and placental efficiency. WHAT IS ...
Opinion
Prognosis-based management of unexplained infertility—why not?
Laxmi Shingshetty and others
Up to a half of couples seeking medical assistance for infertility are diagnosed with unexplained infertility, characterized by normal ovulation, tubal patency, and semen analysis results. This condition presents a challenge in determining the optimal treatment approach. Available treatments ...
Original Article
Blood pressure and lipid profiles in children born after ART with frozen embryo transfer
Louise Laub Asserhøj and others
STUDY QUESTION Are blood pressure (BP) and lipid profiles different between children conceived after ART with frozen embryo transfer (FET), fresh embryo transfer (fresh-ET), and natural conception (NC)? SUMMARY ANSWER Girls conceived after FET had significantly higher systolic BP and heart rate ...
Original Article
Extracellular vesicles secreted by human aneuploid embryos present a distinct transcriptomic profile and upregulate MUC1 transcription in decidualised endometrial stromal cells
Sofia Makieva and others
STUDY QUESTION Do extracellular vesicles (EVs) secreted by aneuploid human embryos possess a unique transcriptomic profile that elicits a relevant transcriptomic response in decidualized primary endometrial stromal cells (dESCs)? SUMMARY ANSWER Aneuploid embryo-derived EVs contain transcripts of ...
Original Article
Ovarian ferroptosis induced by androgen is involved in pathogenesis of PCOS
Xinyu Li and others
STUDY QUESTION Does ovarian ferroptosis play an active role in the development of polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Increased ovarian ferroptosis was present in PCOS ovaries and the inhibition of ferroptosis with ferrostatin-1 (Fer-1) ameliorated polycystic ovary morphology and ...
Original Article
Blastocyst telomere length predicts successful implantation after frozen-thawed embryo transfer
Chun-Wei Chien and others
STUDY QUESTION Do embryos with longer telomere length (TL) at the blastocyst stage have a higher capacity to survive after frozen-thawed embryo transfer (FET)? SUMMARY ANSWER Digitally estimated TL using low-pass whole genome sequencing (WGS) data from the preimplantation genetic testing for ...

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Kate Brian, lay editor of HROpen, discusses how scientific research can be skewed in the media and how important it is for patients to have access to clearer summaries of reproductive medicine research. 

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