CLIC1 - Wikipedia
CLIC1
Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1gene.[4][5]
CLIC1
Available structures
Ortholog search: PDBe RCSB
List of PDB id codes
Identifiers
AliasesCLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1
External IDsOMIM: 602872 MGI: 2148924 HomoloGene: 20343 GeneCards: CLIC1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.33Start31,730,581 bp[1]
End31,739,763 bp[1]
Gene ontology
Molecular functionvoltage-gated ion channel activity
GO:0001948 protein binding
chloride channel activity
cadherin binding
glutathione transferase activity
Cellular componentcytoplasm
integral component of membrane
vesicle
nuclear membrane
blood microparticle
nuclear envelope
membrane
plasma membrane
chloride channel complex
mitochondrion
brush border
perinuclear region of cytoplasm
extracellular exosome
nucleus
extracellular space
Biological processregulation of ion transmembrane transport
ion transport
regulation of cell cycle
regulation of mitochondrial membrane potential
positive regulation of osteoblast differentiation
chloride transport
platelet aggregation
signal transduction
chloride transmembrane transport
glutathione metabolic process
transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
ENSG00000213719
ENSG00000223639
ENSG00000226248
ENSG00000226651
ENSG00000226417
ENSG00000230685
ENSG00000206394
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 6: 31.73 – 31.74 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[5]
Interactions
CLIC1 has been shown to interact with TRAPPC2.[6]
See also
Chloride channel
References
  1. ^ a b c ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 GRCh38: Ensembl release 89: ENSG00000213719, ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J Biol Chem. 272 (19): 12575–82. doi​:​10.1074/jbc.272.19.12575​. PMID 9139710.
  5. ^ a b "Entrez Gene: CLIC1 chloride intracellular channel 1".
  6. ^ Fan, Libin; Yu Wei; Zhu Xueliang (Apr 2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. Netherlands. 540 (1–3): 77–80. doi​:​10.1016/S0014-5793(03)00228-X​. ISSN 0014-5793. PMID 12681486. S2CID 8573651.
Further reading
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Last edited on 31 December 2020, at 02:37
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