An event-related potential
) is the measured brain
response that is the direct result of a specific sensory
, or motor
More formally, it is any stereotyped electrophysiological
response to a stimulus. The study of the brain in this way provides a noninvasive
means of evaluating brain functioning.
A waveform showing several ERP components, including the N100
(labeled N1) and P300
(labeled P3). Note that the ERP is plotted with negative voltages upward, a common, but not universal, practice in ERP research
With the discovery of the electroencephalogram
(EEG) in 1924, Hans Berger
revealed that one could measure the electrical activity of the human brain by placing electrodes
on the scalp and amplifying the signal. Changes in voltage can then be plotted over a period of time. He observed that the voltages could be influenced by external events that stimulated the senses. The EEG proved to be a useful source in recording brain activity over the ensuing decades. However, it tended to be very difficult to assess the highly specific neural process that are the focus of cognitive neuroscience
because using pure EEG data made it difficult to isolate individual neurocognitive
processes. Event-related potentials (ERPs) offered a more sophisticated method of extracting more specific sensory, cognitive, and motor events by using simple averaging techniques. In 1935–1936, Pauline and Hallowell Davis
recorded the first known ERPs on awake humans and their findings were published a few years later, in 1939. Due to World War II
not much research was conducted in the 1940s, but research focusing on sensory issues picked back up again in the 1950s. In 1964, research by Grey Walter
and colleagues began the modern era of ERP component discoveries when they reported the first cognitive ERP component, called the contingent negative variation
Sutton, Braren, and Zubin (1965) made another advancement with the discovery of the P3 component.
Over the next fifteen years, ERP component research became increasingly popular. The 1980s, with the introduction of inexpensive computers, opened up a new door for cognitive neuroscience research. Currently, ERP is one of the most widely used methods in cognitive neuroscience
research to study the physiological
correlates of sensory
activity associated with processing information.
ERPs can be reliably
measured using electroencephalography
(EEG), a procedure that measures electrical
activity of the brain over time using electrodes
placed on the scalp
. The EEG reflects thousands of simultaneously ongoing brain processes
. This means that the brain response to a single stimulus or event of interest is not usually visible in the EEG recording of a single trial. To see the brain's response to a stimulus, the experimenter must conduct many trials and average the results together, causing random brain activity to be averaged out and the relevant waveform to remain, called the ERP.
The random (background
) brain activity together with other bio-signals (e.g., EOG
) and electromagnetic interference (e.g., line noise
, fluorescent lamps) constitute the noise contribution to the recorded ERP. This noise obscures the signal of interest, which is the sequence of underlying ERPs under study. From an engineering point of view it is possible to define the signal-to-noise ratio
(SNR) of the recorded ERPs. Averaging increases the SNR of the recorded ERPs making them discernible and allowing for their interpretation. This has a simple mathematical explanation provided that some simplifying assumptions are made. These assumptions are:
- The signal of interest is made of a sequence of event-locked ERPs with invariable latency and shape
- The noise can be approximated by a zero-mean Gaussian random process of variance which is uncorrelated between trials and not time-locked to the event (this assumption can be easily violated, for example in the case of a subject doing little tongue movements while mentally counting the targets in an experiment).
Having defined , the trial number, and , the time elapsed after the th
event, each recorded trial can be written as
is the signal and
is the noise (Note that, under the assumptions above, the signal does not depend on the specific trial while the noise does).
For this reason the noise amplitude of the average of
trials is expected to deviate from the mean (which is
) by less or equal than
in 68% of the cases. In particular, the deviation wherein 68% of the noise amplitudes lie is
times that of a single trial. A larger deviation of
can already be expected to encompass 95% of all noise amplitudes.
Wide amplitude noise (such as eye blinks or movement artifacts
) are often several orders of magnitude larger than the underlying ERPs. Therefore, trials containing such artifacts should be removed before averaging. Artifact rejection can be performed manually by visual inspection or using an automated procedure based on predefined fixed thresholds (limiting the maximum EEG amplitude or slope) or on time-varying thresholds derived from the statistics of the set of trials.
Nomenclature of ERP components
ERP waveforms consist of a series of positive and negative voltage deflections, which are related to a set of underlying components
Though some ERP components are referred to with acronyms (e.g., contingent negative variation
– CNV, error-related negativity
– ERN), most components are referred to by a letter (N/P) indicating polarity (negative/positive), followed by a number indicating either the latency in milliseconds or the component's ordinal
position in the waveform. For instance, a negative-going peak that is the first substantial peak in the waveform and often occurs about 100 milliseconds after a stimulus is presented is often called the N100
(indicating its latency is 100 ms after the stimulus and that it is negative) or N1 (indicating that it is the first peak and is negative); it is often followed by a positive peak, usually called the P200
or P2. The stated latencies for ERP components are often quite variable, particularly so for the later components that are related to the cognitive processing of the stimulus. For example, the P300
component may exhibit a peak anywhere between 250 ms – 700 ms.
Advantages and disadvantages
Relative to behavioral measures
Compared with behavioral procedures, ERPs provide a continuous measure of processing between a stimulus and a response, making it possible to determine which stage(s) are being affected by a specific experimental manipulation. Another advantage over behavioral measures is that they can provide a measure of processing of stimuli even when there is no behavioral change. However, because of the significantly small size of an ERP, it usually takes a large number of trials to accurately measure it correctly.
Relative to other neurophysiological measures
Unlike microelectrodes, which require an electrode to be inserted into the brain, and PET
scans that expose humans to radiation, ERPs use EEG, a non-invasive procedure.
Spatial and temporal resolution
ERPs provide excellent temporal resolution
—as the speed of ERP recording is only constrained by the sampling rate that the recording equipment can feasibly support, whereas hemodynamic
measures (such as fMRI
, and fNIRS
) are inherently limited by the slow speed of the BOLD
response. The spatial resolution
of an ERP, however, is much poorer than that of hemodynamic methods—in fact, the location of ERP sources is an inverse problem
that cannot be exactly solved, only estimated. Thus, ERPs are well suited to research questions about the speed of neural activity, and are less well suited to research questions about the location of such activity.
ERP research is much cheaper to do than other imaging techniques such as fMRI
, and MEG
. This is because purchasing and maintaining an EEG system is less expensive than the other systems.
will sometimes use a flashing visual
checkerboard stimulus to test for any damage or trauma in the visual system. In a healthy person, this stimulus will elicit a strong response over the primary visual cortex
located in the occipital lobe
, in the back of the brain.
ERP component abnormalities in clinical research have been shown in neurological conditions such as:
ERPs are used extensively in neuroscience
, cognitive psychology
, cognitive science
, and psycho-physiological
research. Experimental psychologists
have discovered many different stimuli that elicit reliable ERPs from participants. The timing of these responses is thought to provide a measure of the timing of the brain's communication or timing of information processing. For example, in the checkerboard paradigm described above, healthy participants' first response of the visual cortex is around 50–70 ms. This would seem to indicate that this is the amount of time it takes for the transduced
visual stimulus to reach the cortex
first enters the eye
. Alternatively, the P300
response occurs at around 300ms in the oddball paradigm
, for example, regardless of the type of stimulus presented: visual
, etc. Because of this general invariance with regard to stimulus type, the P300 component is understood to reflect a higher cognitive response to unexpected and/or cognitively salient
stimuli. The P300 response has also been studied in the context of information and memory detection.
In addition, there are studies on abnormalities of P300 in depression. Depressed patients tend to have a reduced P200 and P300 amplitude and a prolonged P300 latency.
Due to the consistency of the P300 response to novel stimuli, a brain-computer interface
can be constructed which relies on it. By arranging many signals in a grid, randomly flashing the rows of the grid as in the previous paradigm, and observing the P300 responses of a subject staring at the grid, the subject may communicate which stimulus he is looking at, and thus slowly "type" words.
Another area of research in the field of ERP lies in the efference copy
. This predictive mechanism plays a central role in for example human verbalization.
Efference copies, however, do not only occur with spoken words, but also with inner language - i.e. the quiet production of words - which has also been proven by event-related potentials.
- ^ a b Luck, Steven J. (2005). An Introduction to the Event-Related Potential Technique. The MIT Press. ISBN 978-0-262-12277-1.[page needed]
- ^ Brown, Colin M; Peter Hagoort (1999). "The cognitive neuroscience of language". In Colin M. Brown and Peter Hagoort (ed.). The Neurocognition of Language. New York: Oxford University Press. p. 6.
- ^ Walter, W. Grey; Cooper, R.; Aldridge, V. J.; McCallum, W. C.; Winter, A. L. (July 1964). "Contingent Negative Variation: An Electric Sign of Sensori-Motor Association and Expectancy in the Human Brain". Nature. 203 (4943): 380–384. Bibcode:1964Natur.203..380W. doi:10.1038/203380a0. PMID 14197376. S2CID 26808780.
- ^ Sutton, S.; Braren, M.; Zubin, J.; John, E. R. (26 November 1965). "Evoked-Potential Correlates of Stimulus Uncertainty". Science. 150 (3700): 1187–1188. Bibcode:1965Sci...150.1187S. doi:10.1126/science.150.3700.1187. PMID 5852977. S2CID 39822117.
- ^ Handy, T. C. (2005). Event Related Potentials: A Methods Handbook. Cambridge, Massachusetts: Bradford/MIT Press.[page needed]
- ^ Coles, M. G. H.; Rugg, M. D. (1995). "Event-related brain potentials: An introduction". In Rugg, M. D.; Coles, M. G. H. (eds.). Electrophysiology of mind: Event-related brain potentials and cognition. Oxford psychology series, No. 25. New York: Oxford University Press. pp. 1–26.
- ^ Luck, S.J.; Kappenman, E.S., eds. (2012). The Oxford Handbook of Event-Related Potential Components. Oxford University Press. p. 664. ISBN 9780195374148.
- ^ Luck, Steven (2005). "Comparison with Behavioral Measures". An Introduction to the Event-Related Potential Technique. MIT Press. pp. 21–23.
- ^ Johnstone, Stuart J.; Barry, Robert J.; Clarke, Adam R. (April 2013). "Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder". Clinical Neurophysiology. 124 (4): 644–657. doi:10.1016/j.clinph.2012.09.006. PMID 23063669. S2CID 13867965.
- ^ Barry, Robert J; Johnstone, Stuart J; Clarke, Adam R (February 2003). "A review of electrophysiology in attention-deficit/hyperactivity disorder: II. Event-related potentials". Clinical Neurophysiology. 114 (2): 184–198. doi:10.1016/S1388-2457(02)00363-2. PMID 12559225. S2CID 9239459.
- ^ Boutros, Nashaat; Torello, Michael W.; Burns, Elizabeth M.; Wu, Shu-Shieh; Nasrallah, Henry A. (June 1995). "Evoked potentials in subjects at risk for Alzheimer's Disease". Psychiatry Research. 57 (1): 57–63. doi:10.1016/0165-1781(95)02597-P. PMID 7568559. S2CID 17010156.
- ^ S, Prabhakar; Syal, P; Srivastava, T (1 July 2000). "P300 in newly diagnosed non-dementing Parkinson's disease : effect of dopaminergic drugs". Neurology India. 48 (3): 239–42. PMID 11025627.
- ^ Boose, Martha A.; Cranford, Jerry L. (1996). "Auditory Event-Related Potentials in Multiple Sclerosis". Otology & Neurotology. 17 (1): 165–70. PMID 8694124.
- ^ Duncan, Connie C.; Kosmidis, Mary H.; Mirsky, Allan F. (28 June 2008). "Event–related potential assessment of information processing after closed head injury". Psychophysiology. 40 (1): 45–59. doi:10.1111/1469-8986.00006. PMID 12751803.
- ^ D'Arcy, Ryan CN; Marchand, Yannick; Eskes, Gail A; Harrison, Edmund R; Phillips, Stephen J; Major, Alma; Connolly, John F (April 2003). "Electrophysiological assessment of language function following stroke". Clinical Neurophysiology. 114 (4): 662–672. doi:10.1016/S1388-2457(03)00007-5. PMID 12686275. S2CID 27955719.
- ^ Hanna, Gregory L.; Carrasco, Melisa; Harbin, Shannon M.; Nienhuis, Jenna K.; LaRosa, Christina E.; Chen, Poyu; Fitzgerald, Kate D.; Gehring, William J. (September 2012). "Error-Related Negativity and Tic History in Pediatric Obsessive-Compulsive Disorder". Journal of the American Academy of Child & Adolescent Psychiatry. 51 (9): 902–910. doi:10.1016/j.jaac.2012.06.019. PMC 3427894. PMID 22917203.
- ^ Ford, Judith M.; Palzes, Vanessa A.; Roach, Brian J.; Mathalon, Daniel H. (July 2014). "Did I Do That? Abnormal Predictive Processes in Schizophrenia When Button Pressing to Deliver a Tone". Schizophrenia Bulletin. 40 (4): 804–812. doi:10.1093/schbul/sbt072. ISSN 0586-7614. PMC 4059422. PMID 23754836.
- ^ Clayson, Peter E.; Wynn, Jonathan K.; Infantolino, Zachary P.; Hajcak, Greg; Green, Michael F.; Horan, William P. (November 2019). "Reward processing in certain versus uncertain contexts in schizophrenia: An event-related potential (ERP) study". Journal of Abnormal Psychology. 128 (8): 867–880. doi:10.1037/abn0000469. ISSN 1939-1846. PMC 6822386. PMID 31657597.
- ^ a b Zhou, Lina; Wang, Gaohua; Nan, Cai; Wang, Huiling; Liu, Zhongchun; Bai, Hanping (January 2019). "Abnormalities in P300 components in depression: an ERP-sLORETA study". Nordic Journal of Psychiatry. 73 (1): 1–8. doi:10.1080/08039488.2018.1478991. ISSN 1502-4725. PMID 30636465. S2CID 58664019.
- ^ McCormick, Brian (2006). "Your Thoughts May Deceive You: The Constitutional Implications of Brain Fingerprinting Technology and How It May Be Used to Secure Our Skies". Law & Psychology Review. 30: 171–84.
- ^ Farwell, L.A.; Donchin, E. (December 1988). "Talking off the top of your head: toward a mental prosthesis utilizing event-related brain potentials". Electroencephalography and Clinical Neurophysiology. 70 (6): 510–23. doi:10.1016/0013-4694(88)90149-6. PMID 2461285.
- ^ Roach, Brian J.; Ford, Judith M.; Biagianti, Bruno; Hamilton, Holly K.; Ramsay, Ian S.; Fisher, Melissa; Loewy, Rachel; Vinogradov, Sophia; Mathalon, Daniel H. (November 2019). "Efference copy/corollary discharge function and targeted cognitive training in patients with schizophrenia". International Journal of Psychophysiology. 145: 91–98. doi:10.1016/j.ijpsycho.2018.12.015. ISSN 0167-8760. PMC 6616012. PMID 30599145.
- ^ Brumberg, Jonathan S.; Pitt, Kevin M. (15 July 2019). "Motor-Induced Suppression of the N100 Event-Related Potential During Motor Imagery Control of a Speech Synthesizer Brain-Computer Interface". Journal of Speech, Language, and Hearing Research: JSLHR. 62 (7): 2133–2140. doi:10.1044/2019_JSLHR-S-MSC18-18-0198. ISSN 1558-9102. PMC 6808362. PMID 31306609.
- ^ Whitford, Thomas J.; Jack, Bradley N.; Pearson, Daniel; Griffiths, Oren; Luque, David; Harris, Anthony Wf; Spencer, Kevin M.; Le Pelley, Mike E. (4 December 2017). "Neurophysiological evidence of efference copies to inner speech". eLife. 6. doi:10.7554/eLife.28197. ISSN 2050-084X. PMC 5714499. PMID 29199947.
- ^ Mueller, Andreas; Candrian, Gian; Kropotov, Juri D; Ponomarev, Valery A; Baschera, Gian-Marco (2010-06-03). "Classification of ADHD patients on the basis of independent ERP components using a machine learning system". Nonlinear Biomedical Physics. 4 (Suppl 1): S1. doi:10.1186/1753-4631-4-S1-S1. ISSN 1753-4631. PMC 2880795. PMID 20522259.
- ^ Frick, J;, Rieg, T. and Buettner, R. 2020. “Detection of schizophrenia: a machine learning algorithm for potential early detection and prevention based on event-related potentials,” in HICSS-54 Proc.
- Steven J. Luck: An Introduction to the Event-Related Potential Technique, Second edition. Cambridge, Massachusetts: The MIT Press, 2014. ISBN 9780262525855.
- Todd C. Handy: Event-Related Potentials : A Methods Handbook. Cambridge, Massachusetts: The MIT Press (B&T), 2004. ISBN 0-262-08333-7
- Luck, S.J., and Kappenman, E.S., ed. (2012). The Oxford Handbook of Event-Related Potential Components. Oxford University Press. pp. 664. ISBN 9780195374148.
- Fabiani, Monica; Gratton, Gabriele; Federmeier, Kara D. (2007). "Event-Related Brain Potentials: Methods, Theory, and Applications". In Cacioppo, John T.; Tassinary, Louis G.; Berntson, Gary G. (eds.). Handbook of Psychophysiology (3rd ed.). Cambridge: Cambridge University. pp. 85–119. ISBN 978-0-521-84471-0.
- Polich, John; Corey-Bloom, Jody (1 December 2005). "Alzheimers Disease and P300: Review and Evaluation of Task and Modality". Current Alzheimer Research. 2 (5): 515–25. doi:10.2174/156720505774932214. PMID 16375655.
- Zani A. & Proverbio A.M. (2003) Cognitive Electrophysiology of Mind and Brain. Academic Press/Elsvier.
- Kropotov J. (2009)" Quantitative EEG, Event-Related Potentials and Neurotherapy" Academic Press/Elsvier.
-  – ERP Summer School 2017 was held in The School of Psychology, Bangor University from 25–30 June 2017
- EEGLAB Toolbox – A freely available, open-source, Matlab toolbox for processing and analyzing EEG data
- ERPLAB Toolbox – A freely available, open-source, Matlab toolbox for processing and analyzing ERP data
- The ERP Boot Camp – A series of training workshops for ERP researchers led by Steve Luck and Emily Kappenman
- Virtual ERP Boot Camp – A blog with information, announcements, and tips about ERP methodology
Last edited on 3 May 2021, at 16:40
Content is available under CC BY-SA 3.0
unless otherwise noted.