Khamis was assigned to the management of a number of departments in the General Organization for the distribution and investment power from 1987 to 2005. He was Director General of the General Company for Electricity for the Damascus Governorate from 2005 to 2008. He was appointed Director-General of the Public Corporation for the distribution and investment power in 2008.
The European Union sanctioned Khamis due to his alleged role in using the electric cuts as a way of repressing Syrian people on 24 March 2012.
According to Al Akhbar, Khamis was detained after he was dismissed from premiership, and has been interrogated due to corruption charges. However, Khamis was seen shortly after, when he was voting during the 2020 Syrian parliamentary election.