Samuel Gross may refer to:
- Samuel D. Gross (1805–1884), pioneering American academic trauma physician
- Samuel Gross (Calder), an 1897 bronze statue by Alexander Stirling Calder
- Samuel Gross (politician) (1776–1839), American congressman from Pennsylvania
- Samuel R. Gross, American law professor
- Samuel Gross (Medal of Honor) (1891–1934), United States Marine Corps private and Medal of Honor recipient
- Sam Gross (born 1933), American cartoonist
This disambiguation page lists articles associated with the title Samuel Gross.
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