Template talk:Transcription factor glossary

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Latest comment: 8 years ago2 comments1 person in discussion

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@Boghog: I'd like to add a collapsed version of this template to Addiction#Mechanisms, but there's 2 things I'd like to add to this template to make it more useful to readers. These are "gene expression" and "transcription factor" - I realize "transcription" and "factor" are already in the template, although I don't think a layperson reading the template in that article is going to be able to figure out what a transcription factor is based upon those 2 individual entries in the template.

By doing this, it wouldn't be necessary to link to Glossary of gene expression terms in the hatnote in that section. Are you okay with adding those? Seppi333 (Insert 2¢) 02:46, 9 February 2016 (UTC)Reply

Edit: perhaps "Level of gene expression" would be more applicable in this particular case, since the text focuses on overexpression. In that glossary, we define "gene expression" as: the transcription of DNA into messenger RNA by RNA polymerase. The messenger RNA is then translated into protein by the ribosome. In gene expression analysis, expression level refers to the amount of mRNA detected in a sample.

In the amphetamine article, the note on transcription factors simply stated "Transcription factors are proteins that increase or decrease the expression of specific genes."^[1] I suppose any of these would work as well: http://ghr.nlm.nih.gov/glossary=transcriptionfactor

If you think adding this wouldn't be appropriate for the articles where this template is transcluded now, I'll make a different glossary for this purpose to avoid a conflict. Seppi333 (Insert 2¢) 03:05, 9 February 2016 (UTC)Reply

References

^ Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 4: Signal Transduction in the Brain". In Sydor A, Brown RY (ed.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York, USA: McGraw-Hill Medical. p. 94. ISBN 9780071481274. All living cells depend on the regulation of gene expression by extracellular signals for their development, homeostasis, and adaptation to the environment. Indeed, many signal transduction pathways function primarily to modify transcription factors that alter the expression of specific genes. Thus, neurotransmitters, growth factors, and drugs change patterns of gene expression in cells and in turn affect many aspects of nervous system functioning, including the formation of long-term memories. Many drugs that require prolonged administration, such as antidepressants and antipsychotics, trigger changes in gene expression that are thought to be therapeutic adaptations to the initial action of the drug.{{cite book}}: CS1 maint: multiple names: authors list (link)

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[NHM-Transcription_factor-1] Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 4: Signal Transduction in the Brain". In Sydor A, Brown RY (ed.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York, USA: McGraw-Hill Medical. p. 94. ISBN 9780071481274. All living cells depend on the regulation of gene expression by extracellular signals for their development, homeostasis, and adaptation to the environment. Indeed, many signal transduction pathways function primarily to modify transcription factors that alter the expression of specific genes. Thus, neurotransmitters, growth factors, and drugs change patterns of gene expression in cells and in turn affect many aspects of nervous system functioning, including the formation of long-term memories. Many drugs that require prolonged administration, such as antidepressants and antipsychotics, trigger changes in gene expression that are thought to be therapeutic adaptations to the initial action of the drug.{{cite book}}: CS1 maint: multiple names: authors list (link)

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