Title From inflammation to cancer : advances in diagnosis and therapy for gastrointestinal and hepatological diseases / edited by Chi-Hin Cho, Jun Yu.

Descript 1 online resource Summary Inflammation and cancer are two major disorders that cause huge concerns in our society. However, what one may not know is that both diseases are closely associated and, in particular, both occur in the gastrointestinal tract and liver. This book describes the mechanics of how inflammation can progress to cancer in these organs. The authors in this book comprehensively discuss the different biomarkers for early diagnosis, and current therapeutic treatments for these diseases. All of these would allow us to better understand the pathogenesis of both diseases. As such, this book provides compreh. Contents Section I. Inflammation and cancer. ch. 1. General introduction / Chung Wah Wu and Jun Yu. ch. 2. General mechanisms of inflammation / Liwei Lu and Min Yang. ch. 3. Genetic and epigenetic alterations in inflammation-related cancers -- General mechanisms of cancers / Yasuyuki Okamoto and Yutaka Kondo. ch. 4. From inflammation to cancer: the molecular basis / Hongchuan Jin -- Section II. Models of chronic inflammation-induced cancers and their treatments. ch. 5. Advances in the treatment of Helicobacter pylori infection and gastric cancer / Guy D. Eslick. ch. 6. Inflammatory bowel disease and colorectal cancer and their treatment / Crispin Corte and Rupert WL Leong. ch. 7. Hepatitis B and hepatocellular carcinoma and their treatment / Chi-Jen Chu, Teh-Ia Huo and Shou-Dong Lee. ch. 8. Hepatitis C and hepatocellular carcinoma: implications for pathogenesis and treatment / Geoffrey C. Farrell. ch. 9. Advances in the interventional therapies for hepatocellular carcinoma / Carmen Chi Min Cho, Joyce Wai Yi Hui and Simon Chun Ho Yu -- Section III. Mediators in chronic inflammation and cancers. ch. 10. Exploration of cytokine signaling in clinical management of hepatocellular carcinoma / Xuelian Zhao and Xin Wei Wang. ch. 11. Role of nuclear factor-[symbol]B pathway in gastrointestinal inflammation and cancer / Muthu K. Shanmugam [and others]. ch. 12. Novel mediators for chronic inflammation and oncogenic transformation: Tumor Necrosis Factor (TNF)-[symbol] / Naofumi Mukaida and Boryana K. Popivanova. ch. 13. Peroxisome Proliferator Activated Receptor-[symbol] (PPAR[symbol]) : roles in chronic inflammation and intestinal oncogenic transformation / Ioannis A. Voutsadakis. ch. 14. Proteinase-activated receptors / Hongying Wang -- Section IV. Molecular markers of cancers and their clinical implications. ch. 15. Use of tumor markers in the detection and management of patients with colorectal cancer / Michael J. Duffy. ch. 16. Genetic biomarkers for the diagnosis and prognosis of hepatocellular carcinoma / John M. Luk [and others] -- Section V. Summary. ch. 17. Current therapy and future perspectives for inflammation-associated cancer / L. Zhang and C.H. Cho. Current model of tumorigenesis: interplay between tumor stem cells and tumor-permissive microenvironmentTumor microenvironment -- Non-tumor cells in tumor microenvironment -- Cancer-associated fibroblast (CAFs) -- Immune cells -- Bioactive factors in tumor microenvironment -- Chemokines -- Growth factors -- MMPs and TIMPs (tissue inhibitors of metalloproteinases) -- Other cytokines -- Intracellular signaling pathways -- NF- ₀ðB (nuclear factor ₀ðlight chain polypeptide gene enhancer in B cells) pathway -- STAT3 (signal transducer and activator of transcription 3) pathway -- Conclusions. Bibliog. Includes bibliographical references and index. Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - Worldwide Marc 505-00/(S Influx of leukocytesEffector mechanisms -- Termination of inflammation and tissue repair -- Regulatory mechanisms of inflammation -- Conclusion -- 3. Genetic and Epigenetic Alterations in Inflammation-Related Cancers -- General Mechanisms of Cancers Yasuyuki Okamoto and Yutaka Kondo -- Introduction -- Signaling pathways -- NF- ₀ðB -- STAT3 -- RAS -- TNF- ₀ł -- TAM -- Genetic instability -- Epigenetic alterations -- DNA methylation -- Histone modifications -- Perspectives -- 4. From Inflammation to Cancer: The Molecular Basis Hongchuan Jin -- Inflammation and cancer: a brief overview of history. Subject Gastrointestinal system -- Cancer -- Diagnosis. Gastrointestinal system -- Cancer -- Treatment. Liver -- Cancer -- Diagnosis. Liver -- Cancer -- Treatment. Digestive System Neoplasms -- etiology Digestive System Neoplasms -- therapy Inflammation -- complications MEDICAL -- Gastroenterology. Gastrointestinal system -- Cancer -- Diagnosis. (OCoLC)fst01767288 Gastrointestinal system -- Cancer -- Treatment. (OCoLC)fst01767296 Liver -- Cancer -- Diagnosis. (OCoLC)fst01000627 Liver -- Cancer -- Treatment. (OCoLC)fst01000631 Alt Author Cho, C.-H. (Chi-Hin) Yu, Jun. ISBN 9789814343602 (electronic bk.) 9814343609 (electronic bk.) 1283635933 9781283635936 661394839X 9786613948397 9814343595 9789814343596