Title Applied biocatalysis : the chemist's enzyme toolbox / edited John Whittall, Peter W. Sutton.

Descript 1 online resource (xviii, 540 pages) : illustrations (some color) Bibliog. Includes bibliographical references and index. Summary "Biocatalysis has had a significant impact on the synthesis of active pharmaceutical ingredients (APIs) in recent years. The main driver for this is the ability to harness the regio- and stereoselectivity of enzymes to improve the efficiency of synthetic routes. For example, enzymes can offer direct access to enantiopure products, where traditional organic synthesis would require either resolution or the use of auxiliary groups [1], whilst applied enzymes have improved syntheses or generated molecules that would otherwise be either impossible or impractical to synthesise."-- Provided by publisher Contents Cover -- Title Page -- Copyright -- Contents -- Abbreviations -- Chapter 1 Directed Evolution of Enzymes Driving Innovation in API Manufacturing at GSK -- 1.1 Introduction -- 1.2 Drug Development Stages -- 1.3 Enzyme Panels -- 1.4 Enzyme Engineering -- 1.5 Case Studies -- 1.6 Outlook -- Chapter 2 Survey of Current Commercial Enzyme and Bioprocess Service Providers -- 2.1 Commercial Enzyme Suppliers/Distributors -- 2.2 Bioprocess Service Providers -- 2.3 Chemical Transformations of Selected Commercially Available Enzymes -- Chapter 3 Imine Reductases 3.1 Imine Reductase-Catalysed Enantioselective Reductive Amination for the Preparation of a Key Intermediate to Lysine-Specific Histone Demethylase 1 (LSD1) Inhibitor GSK2879552 -- 3.2 Expanding the Collection of Imine Reductases Towards a Stereoselective Reductive Amination -- 3.3 Asymmetric Synthesis of the Key Intermediate of Dextromethorphan Catalysed by an Imine Reductase -- 3.4 Identification of Imine Reductases for Asymmetric Synthesis of 1-Aryl-tetrahydroisoquinolines -- 3.5 Preparation of Imine Reductases at 15 L Scale and Their Application in Asymmetric Piperazine Synthesis 5.4 Convenient Approach to the Biosynthesis of C2,C6-Disubstituted Purine Nucleosides Using E. coli Purine Nucleoside Phosphorylase and Arsenolysis -- 5.5 Production of L- and D-Phenylalanine Analogues Using Tailored Phenylalanine Ammonia-Lyases -- 5.6 Asymmetric Reductive Amination of Ketones Catalysed by Amine Dehydrogenases -- 5.7 Utilisation of Adenylating Enzymes for the Formation of N-Acyl Amides -- Chapter 6 Carbon-Carbon Bond Formation or Cleavage -- 6.1 An Improved Enzymatic Method for the Synthesis of (R)-Phenylacetyl Carbinol Local Note John Wiley and Sons Wiley Online Library UBCM All Obooks Marc m o d Subject Biocatalysis. Biocatalysis Biocatalysis Alt Author Whittall, John, editor. Sutton, Peter (Peter W.), editor. ISBN 9781119487036 electronic book 111948703X electronic book 9781119487029 electronic book 1119487021 electronic book 9781119487043 electronic book 1119487048 electronic book 9781119487012 hardcover 1119487013 hardcover