| | List of Section Editors | |
| | List of Contributors | |
| | Preface | |
| | Introduction: The Role of Animal Models in the Evaluation of New Antibodies / O. Zak, M. A. Sande, T. O'Reilly | |
| I | Introductory Background to Animal Models of Infection / O. Zak | 1 |
| | 1 | Early History of Animal Models of Infection / A. Contrepois, A.-M. Moulin | 3 |
| | 2 | General Methodologies for Animal Models / M. S. Rouse, W. R. Wilson | 9 |
| | 3 | Ethics Committees in Europe - An Overview / P. de Greeve, W. de Leeuw | 13 |
| | 4 | Animal Care and Use Committees - An American Perspective / T. Allen, R. Crawford | 19 |
| | 5 | Ethical Aspects of the Use of Animal Models of Infection / D. B. Morton | 29 |
| | 6 | The Impact of General Laboratory Animal Health on Experimental Models in Antimicrobial Chemotherapy / A. K. Hansen | 49 |
| | 7 | Non-invasive Monitoring of Infection and Gene Expression in Living Animal Models / P. R. Contag, A. B. Olomu, C. H. Contag | 61 |
| | 8 | Considerations for Working Safely with Infectious Disease Agents in Research Agents / J. Y. Richmond, F. Quimby | 69 |
| | 9 | Analysis of Genetic Susceptibility to Infection in Mice / E. Buschman, E. Skamene | 75 |
| | 10 | Formulation of Compounds and Determination of Pharmacokinetic Parameters / R. M. Cozens | 83 |
| | 11 | Methods for Obtaining Human-like Pharmacokinetic Patterns in Experimental Animals / L. Mizen | 93 |
| | 12 | Modes of Action of Antibiotics and Bacterial Structure: Bacterial Mass Versus their Numbers / V. Lorian | 105 |
| | 13 | Activity of Antibiotics Against Adherent/Slow-growing Bacteria Reflecting the Situation in vivo / I. Foley, M. R. W. Brown | 117 |
| II | Bacterial Infection Models / C. Carbon, B. Fantin, T. O'Reilly | 125 |
| | 14 | The Mouse Peritonitis/Sepsis Model / N. Frimodt-Moller, J. D. Knudsen, F. Espersen | 127 |
| | 15 | Murine Thigh Infection Model / S. Gudmundsson, H. Erlensdottir | 137 |
| | 16 | Mouse Subcutaneous Cotton Thread Model / J. Renneberg | 145 |
| | 17 | Infection after Ionizing Radiation / I. Brook, T. B. Elliott, G. D. Ledney | 151 |
| | 18 | Intra-abdominal Abscess / I. Brook | 163 |
| | 19 | Mouse Peritonitis Model Using Cecal Ligation and Puncture / M. Shroti, J. C. Peyton, W. G. Cheadle | 173 |
| | 20 | Murine Models of Peritonitis Involving a Foreign Body / F. Espersen, N. Frimodt-Moller | 183 |
| | 21 | Rat Polymicrobial Peritonitis Infection Model / H. Dupont, P. Montravers | 189 |
| | 22 | Murine Thigh Suture Model / J. D. Pietsch, H. C. Polk, Jr. | 195 |
| | 23 | Animal Models of Melioidosis / D. De Shazer, D. E. Woods | 199 |
| | 24 | Low Inoculum Model of Clean Wound Infection / A. B. Kaiser, D. S. Kernodle | 205 |
| | 25 | Translocation of Gut Bacteria During Trauma / L. Magnotti, D.-Z. Xu, E. A. Deitch | 213 |
| | 26 | Mouse Models of Campylobacter jejuni Infection / S. Baqar, E. F. Burg III, J. R. Murphy | 223 |
| | 27 | Suckling Mouse Model of Enterotoxigenic Escherichia coli Infection / M. Duchet-Suchaux | 241 |
| | 28 | Rabbit Model of Shigellosis / M. E. Etheridge | 255 |
| | 29 | RITARD Rabbit Model for Studying Vibrio cholerae and Other Enteric Infections / P. Panigrahi, J. G. Morris, Jr. | 261 |
| | 30 | Mouse Model of Helicobacter pylori Infection / P. Ghiara, G. del Giudice, R. Rappuoli | 265 |
| | 31 | Animal Models of Helicobacter (ferrets) / R. P. Marini, J. G. Fox | 273 |
| | 32 | Hamster Model of Syphilis / J. D. Alder | 285 |
| | 33 | Guinea-pig Model of Acquired and Congenital Syphilis / V. Wicher, K. Wicher | 291 |
| | 34 | The Guinea-pig Model of Legionnaires' Disease / P. H. Edelstein | 303 |
| | 35 | Murine Models of Tuberculosis / I. M. Orme | 315 |
| | 36 | Beige Mouse Model of Disseminated Mycobacterium avium Complex Infection / M. H. Cynamon, M. S. DeStefano | 321 |
| | 37 | The Armadillo Leprosy Model, with Particular Reference to Lepromatous Neuritis / D. M. Scollard, R. W. Truman | 331 |
| | 38 | Models of Leprosy Infection in Mice / B. Ji, L. Levy | 337 |
| | 39 | Hamster Model of Lyme Arthritis / R. F. Schell, S. M. Callister | 347 |
| | 40 | Rabbit Model of Bacterial Conjunctivitis / M. Motschmann, W. Behrens-Baumann | 353 |
| | 41 | Murine Model of Bacterial Keratitis / K. A. Kernacki, J. A. Hobden, L. D. Hazlett | 361 |
| | 42 | The Rabbit Intrastromal Injection Model of Bacterial Keratitis / R. J. O'Callaghan, L. S. Engel, J. M. Hill | 367 |
| | 43 | Gerbil Model of Acute Otitis Media / B. Barry, M. Muffat-Joly | 375 |
| | 44 | Bacterial Otitis Externa in the Guinea-pig Model / S. A. Estrem | 385 |
| | 45 | Otitis Media: The Chinchilla Model [et al.] / D. M. Hajek, Z. Yuan, M. K. Quartey | 389 |
| | 46 | A Guinea Pig Model of Acute Otitis Media / T. G. Takoudes, J. Haddad, Jr. | 403 |
| | 47 | Tissue Cage Infection Model / W. Zimmerli | 409 |
| | 48 | Rat Model of Bacterial Epididymitis / H. G. Schiefer, C. Jantos | 419 |
| | 49 | Mouse Model of Mycoplasma Genital Infections / D. Taylor-Robinson, P. M. Furr | 427 |
| | 50 | Mouse Model of Ascending Urinary Tract Infection / W. J. Hopkins | 435 |
| | 51 | Mouse Model of Ascending UTI Involving Short and Long-term Indwelling Catheters / D. E. Johnson, C. V. Lockatell | 441 |
| | 52 | Rat Bladder Infection Model / T. Matsumoto | 447 |
| | 53 | Rabbit Model of Catheter-associated Urinary Tract Infection [et al.] / D. W. Morck, M. E. Olson, R. R. Read | 453 |
| | 54 | Subclinical Pyelonephritis in the Rat / G. Findon | 463 |
| | 55 | Models of Acute and Chronic Pyelonephritis in the Rat / G. Findon | 469 |
| | 56 | Rat Model of Chronic Cystitis / D. J. Ormrod, T. E. Miller | 475 |
| | 57 | Mouse Pneumococcal Pneumonia Models / E. Azoulay-Dupuis, P. Moine | 481 |
| | 58 | Animal Models of Gram-negative Bacillary Experimental Pneumonia / M. S. Rouse, J. M. Steckelberg | 495 |
| | 59 | Models of Pneumonia in Ethanol-treated Rats / M. J. Gentry, L. C. Preheim | 501 |
| | 60 | Pneumococcal Pneumonia and Bacteria in a Cirrhotic Rat Model / L. C. Preheim, G. L. Gorby, M. J. Gentry | 509 |
| | 61 | Rat Model of Chronic Pseudomonas aeruginosa Lung Infection / H. K. Johansen, N. Hoiby | 517 |
| | 62 | Hamster Model of Mycoplasma Pulmonary Infections / K. Ishida, M. Kaku, J. Shimada | 527 |
| | 63 | Murine Models of Pneumonia Using Aerosol Inoculation / J. Leggett | 533 |
| | 64 | Experimental Models of Infectious Arthritis / T. Bremell | 539 |
| | 65 | Experimental Group B Streptococcus Arthritis in Mice / L. Tissi | 549 |
| | 66 | Rat Model of Bacterial Osteomyelitis of the Tibia / T. O'Reilly, J. T. Mader | 561 |
| | 67 | Hematogenous Osteomyelitis in the Rat [et al.] / S. A. Hienz, C. E. Nord, A. Heimdahl | 577 |
| | 68 | Rabbit Model of Bacterial Osteomyelitis of the Tibia / J. T. Mader, M. E. Shirtliff | 581 |
| | 69 | Arthroplasty Model in Rats / J. Renneberg, K. Piper, M. Rouse | 593 |
| | 70 | Arthroplasty Model in Rabbits / N. S. Soe-Nielsen, J. Renneberg | 599 |
| | 71 | Mouse Model of Streptococcal Fasciitis / S. Sriskandan, J. Cohen | 605 |
| | 72 | Rabbit Model of Bacterial Endocarditis / A. Lefort, B. Fantin | 611 |
| | 73 | Infant Rat Model of Acute Meningitis / U. Vogel, M. Frosch | 619 |
| | 74 | Adult Rat Model of Meningitis / G. C. Townsend, W. M. Scheld | 627 |
| | 75 | Rabbit Model of Bacterial Meningitis / J. Tureen, E. Tuomanen | 631 |
| | 76 | Escherichia coli Brain Abscess Method in Rat / J. M. Nazzaro, E. A. Neuwelt | 639 |
| III | Mycotic Infection Models / C. Carbon, B. Fantin, T. O'Reilly | 647 |
| | 77 | Rodent Models of Candida Sepsis / V. Joly, P. Yeni | 649 |
| | 78 | A Generalized Candida albicans Infection Model in the Rat / A. Schmidt | 657 |
| | 79 | Experimental Oropharyngeal and Gastrointestinal Candida Infection in Mice [et al.] / A. M. Flattery, G. K. Abruzzo, C. G. Gill | 663 |
| | 80 | Paw Oedema as a Model of Localized Candidiasis / G. Findon | 667 |
| | 81 | Murine Model of Allergic Bronchopulmonary Aspergillosis / P. Dussault, M. Laviolette, G. M. Tremblay | 673 |
| | 82 | Experimental Pulmonary Cryptococcal Infection in Mice [et al.] / M. F. Lipscomb, C. R. Lyons, A. A. Izzo | 681 |
| | 83 | Experimental Pulmonary Cryptococcus neoformans Infection in Rats / D. L. Goldman, A. Casadevall | 687 |
| | 84 | Rat Model of Invasive Pulmonary Aspergillosis / A. C. A. P. Leenders, E. W. M. van Etten, I. A. J. M. Bakker-Woudenberg | 693 |
| | 85 | Rabbit Model of Candida Keratomycosis / M. Motschmann, W. Behrens-Baumann | 697 |
| | 86 | Experimental Candida Endocarditis / M. R. Yeaman, J. Lee, A. S. Bayer | 709 |
| | 87 | Rabbit Model of Cryptococcal Meningitis / J. R. Perfect | 721 |
| | 88 | Rat Models of Ascending Pyelonephritis Due to Candida albicans [et al.] / M. Ohkawa, M. Takashima, T. Nishikawa | 727 |
| | 89 | Rat Model of Candida Vaginal Infection / F. de Bernardis, R. Lorenzini, A. Cassone | 735 |
| | 90 | Murine Models of Candida Vaginal Infections / P. L. Fidel, Jr., J. D. Sobel | 741 |
| | 91 | Sporotrichosis / A. Polak-Wyss | 749 |
| IV | Parasitic Infection Models / R. Kaminsky | 755 |
| | 92 | Malaria / W. Peters, B. L. Robinson | 757 |
| | 93 | Animal Models of Cutaneous Leishmaniasis / V. Yardley, S. L. Croft | 775 |
| | 94 | Animal Models of Visceral Leishmaniasis / S. L. Croft, V. Yardley | 783 |
| | 95 | Animal Models of Acute (first-stage) Sleeping Sickness / R. Brun, R. Kaminsky | 789 |
| | 96 | Animal Models of CNS (second-stage) Sleeping Sickness / C. Gichuki, R. Brun | 795 |
| | 97 | Animal Models of Trypanosoma cruzi Infection / M. M. do Canto Cavalheiro, L. L. Leon | 801 |
| | 98 | Animal Models of Toxoplasma Infection / K. Janitschke | 811 |
| | 99 | Animal Models of Coccidia Infection / A. Haberkorn, G. Greif | 821 |
| | 100 | Animal Models of Trichomonas vaginalis Infection with Special Emphasis on the Intravaginal Mouse Model / S. F. Hayward-McClelland, K. L. Delgaty, G. E. Garber | 839 |
| | 101 | Animal Models of Cryptosporidium Gastrointestinal Infection / D. S. Lindsay, B. L. Blagburn, S. J. Upton | 851 |
| | 102 | Animal Models of Entamoeba histolytica Infection / S. L. Stanley, Jr., T. Zhang, K. B. Seydel | 859 |
| | 103 | Animal Models of Giardiasis / R. C. A. Thompson | 867 |
| | 104 | Schistosomosis / G. C. Coles | 873 |
| | 105 | Animal Models for Echinococcosis / T. Romig, B. Bilger | 877 |
| | 106 | Intestinal Worm Infections / S. S. Johnson, E. M. Thomas, T. G. Geary | 885 |
| V | Viral Infection Models / E. R. Kern | 897 |
| | 107 | Animal Models for Central Nervous System and Disseminated Infections with Herpes Simplex Virus / E. R. Kern | 899 |
| | 108 | Animal Models of Herpesvirus Genital Infection: Guinea-Pig / N. Bourne, L. R. Stanberry | 907 |
| | 109 | Animal Models of Herpes Skin Infection: Guinea-pig / M. B. McKeough, S. L. Spruance | 911 |
| | 110 | Animal Models of Ocular Herpes Simplex Virus Infection (Rabbits, Primates, Mice) [et al.] / B. M. Gebhardt, E. D. Varnell, J. M. Hill | 919 |
| | 111 | Animal Models for Cytomegalovirus Infection: Murine CMV / E. R. Kern | 927 |
| | 112 | Animal Models for Cytomegalovirus Infection: Guinea-Pig CMV / D. I. Bernstein, N. Bourne | 935 |
| | 113 | Animal Models for Cytomegalovirus Infection: Rat CMV / F. S. Stals | 943 |
| | 114 | Human Cytomegalovirus Infection of the SCID-hu (thy/liv) Mouse / G. W. Kemble, G. M. Duke, E. S. Mocarski | 951 |
| | 115 | Animal Model for Ocular Human Cytomegalovirus Infections in SCID-hu Mice [et al.] / D. J. Bidanset, M. del Cerro, E. S. Lazar | 957 |
| | 116 | Animal Models for Varicella Zoster Infections: Simian Varicella / K. F. Soike | 963 |
| | 117 | Varicella Zoster Infection of T cells and Skin in the SCID-hu Mouse Model / J. F. Moffat, A. M. Arvin | 973 |
| | 118 | The Mouse Model of Influenza Virus Infection / R. W. Sidwell | 981 |
| | 119 | The Ferret as an Animal Model of Influenza Virus Infection / C. Sweet, R. J. Fenton, G. E. Price | 989 |
| | 120 | The Cotton Rat as a Model of Respiratory Syncytial Virus Pathogenesis, Prophylaxis and Therapy / G. A. Prince | 999 |
| | 121 | Animal Models for Coxsackievirus Infections / C. J. Gauntt | 1005 |
| | 122 | Animal Models for HBV Infections - Transgenic Mice / J. D. Morrey, R. W. Sidwell, B. A. Korba | 1009 |
| | 123 | Animal Models for Hepatitis B Infections - Duck Hepatitis / T. Shaw, C. A. Luscombe, S. A. Locarnini | 1021 |
| | 124 | Woodchuck Model of Hepatitis B Virus Infection / B. C. Tennant | 1033 |
| | 125 | Animal Models of Papillomavirus Infections / N. D. Christensen, J. W. Kreider | 1039 |
| | 126 | Adult Mouse Model for Rotavirus / R. L. Ward, M. M. McNeal | 1049 |
| | 127 | Animal Models for Lentivirus Infections - Feline Immunodeficiency Virus / M. J. Burkhard, E. A. Hoover | 1055 |
| | 128 | Animal Models of HIV Infection: SIV Infection of Macaques / K. K. A. Van Rompay, N. L. Aguirre | 1061 |
| | 129 | The SCID-hu Thy-Liv Mouse: an Animal Model for HIV-1 Infection / C. A. Stoddart | 1069 |
| | 130 | Animal Models for HIV Infection: hu-PBL-SCID Mice / D. E. Mosier | 1077 |
| | 131 | Chimpanzee Model of HIV-1 Infection / P. N. Fultz | 1085 |
