Abstract: Mass spectrometer parameters used to tune a mass spectrometer for multiple reaction monitoring (MRM) are determined from a single injection of a sample. Two or more precursor ion scans and a plurality of product ion scans for each precursor ion scan are performed from the injection. Each precursor ion scan is produced with different mass spectrometer parameters that create a different level of ion current. The mass spectra of the precursor ion scans are analyzed to determine if saturation has occurred in any of the precursor ion scans. A precursor ion scan that produces the highest ion current with the least amount of saturation is selected. The mass spectrometer parameters used to tune the mass spectrometer for MRM are determined from (1) the mass spectrometer parameters of the selected precursor ion scan and (2) the mass spectrometer parameters of product ion scans from fragments of the selected precursor ion scan.

Abstract: Machine vision is used to identify a discontinuity in the boundary of an object in an image. An image of one or more objects is captured. One or more skeletons of the one or more objects are calculated. One or more boundaries of the one or more objects are calculated. A plurality of radial lines is extended from a spine point of a skeleton to the one or more boundaries. Each radial line intersects a boundary at a radial endpoint producing a plurality of radial endpoints. For each radial endpoint an expected radial endpoint is calculated based on two or more neighboring radial endpoints. If the difference between the radial endpoint and its expected radial endpoint exceeds a threshold, a radial line including the radial endpoint is identified as a discontinuity in a boundary of an object.

Abstract: This invention improves upon existing pay-per-click arrangements periodically generating a code associated with the search-engine users. This code, preferably in the form of a serial number, is compared to the user of the website, such that by observing a metric like the number of clicks for a given period of time, be it a short time or a longer period, such as a day or a week, the system can automatically determine if certain clicks are illegitimate. This allows the pay-per-click company to more fairly invoice the merchants, thereby preventing fraudulent over use.

Abstract: An embodiment of the present invention is a system for identifying a user by observing irregularities on the surface of an eyeball of the user includes a topography system and a gaze tracking system. The topography system obtains one or more discernable features of the eyeball and stores the one or more discernable features. The gaze tracking system observes the irregularities, compares the irregularities to the one or more discernable features, and identifies the user if the irregularities and the one or more discernable features match.

Abstract: A target is imaged in a three-dimensional real space using two or more video cameras. A three-dimensional image space combined from two video cameras of the two or more video cameras is displayed to a user using a stereoscopic display. A right eye and a left eye of the user are imaged as the user is observing the target in the stereoscopic video display, a right gaze line of the right eye and a left gaze line of the left eye are calculated in the three-dimensional image space, and a gazepoint in the three-dimensional image space is calculated as the intersection of the right gaze line and the left gaze line using a binocular eyetracker. A real target location is determined by translating the gazepoint in the three-dimensional image space to the real target location in the three-dimensional real space from the locations and the positions of the two video cameras using a processor.

Abstract: This invention relates generally to a method and system for storing, retrieving, and managing data for tags that are associated in some manner to any type of object. More particularly, the present invention writes data to these tags, reads data from these tags, and manages data that is written to and/or read from these tags. In addition, the invention accesses and/or stores data associated with tags from or into repositories, constructs and maintains data structures from these repositories and responds to queries using the data structures.

Abstract: Reference features are updated based on a previous scan during each mass spectrometry scan of a sample. Reference features with reference feature confidence values are generated from a plurality of initial scans. For each subsequent scan of a sample, sample features and sample feature confidence values are calculated. The reference features and sample features are aligned to determine common features. Constants are determined for an equation of mass of the mass spectrometer using confidence weighted regression of the common features. The constants and the equation of mass are used to calculate new mass values for the sample features. The reference features are updated using the sample features and the reference feature confidence values are recalculated in order to maintain the accuracy of reference features for calibration.

Abstract: Computer-implementable methods consistent with the present teachings can be used in the design of selective- and multiple-reaction monitoring experiments for the identification of proteins and peptides of interest. By determining candidate parent-daughter ion transition pairs and scoring the pairs based on their ability to be detected experimental design time can be reduced and with a more focused list of transition pairs more experiments can be run successfully in a given period of time.

Abstract: Two or more data packets transmitted through a wireless channel are received using a receiver device. The two or more data packets are a result of two or more transmissions that are made sequentially in time at different center frequencies in order to span a desired bandwidth. Each data packet of the two or more data packets is transmitted at a single center frequency. Time differences and/or carrier phase differences among the two or more transmissions are estimated. A time-of-arrival of one or more data packets of the two or more data packets is calculated using each data packet of the two or more data packets and one or more of the estimated time differences, the different center frequencies, and the estimated carrier phase differences.

Abstract: Systems and methods are provided for utilizing a digital coin. A bit string is received. The number of bits in the bit string represents a coin value of the digital coin. The individual bit values of the bits of the bit string are used to determine an identity of the digital coin. The identity of the digital coin is validated by a node of an authentication hierarchy. The validation includes comparing bit values of at least a portion of the bits of the bit string to bit values of corresponding bits of known bit strings that represent known issued digital coins. The validation also includes checking that a matching known issued digital coin was not previously redeemed. A digital coin can also be split into multiple digital coins that are each a continuous sequence of bits of the bit string of the original digital coin.

Abstract: Webpages at a universal resource locator (URL) address are compared at two different times. A request is received from a web browser for a first webpage at the URL. The first webpage is requested and received from the URL at a first time. A selectable webpage is created by editing the first webpage to make it selectable and the selectable web page is sent to the web browser. A selection is received from the web browser that includes a portion of the selectable web page and a frequency. An application is created that retrieves a webpage from the universal resource locator address of the website periodically at the frequency. A second webpage is received from the application that was retrieved from the universal resource locator address at a second time by the application. A portion of the second webpage is compared to the portion of the selectable webpage.

Abstract: Groups of correlated representations of variables are identified from a large amount of spectrometry data. A plurality of samples is analyzed and a plurality of measured variables is obtained from a spectrometer. A processor executes a number of steps. The plurality of measured variables is divided into a plurality of measured variable subsets. Principal component analysis followed by variable grouping (PCVG) is performed on each measured variable subset, producing one or more group representations for each measured variable subset and a plurality of group representations for the plurality of measured variable subsets. While the total number of the plurality of group representations is greater than a maximum number, the plurality of group representations is divided into a plurality of representative subsets and PCVG is performed on each subset. PCVG is performed on the remaining the plurality of group representations, producing a plurality of groups of correlated representations of variables.

Abstract: A sequence of two or more signals representing two or more data packets is transmitted through a wireless channel using a transmitter device. The two or more signals are a result of two or more transmissions that are made sequentially in time at different center frequencies in order to span a desired bandwidth. At least one of the two or more signals includes a physical layer preamble. The sequence of two or more signals is received using a receiver device. A time of arrival of one or more signals of the received sequence is calculated using one or more of the received sequence, the time differences among the two or more transmissions, the different center frequencies, information from the two or more data packets, and any carrier phase differences among the two or more transmissions using the receiver device.

Abstract: A swing training apparatus includes a first plate, a second, plate, a moveable joint, and an angular resistance mechanism. The movable joint connects the first plate to the second plate so that the first plate can rotate with respect to the second plate and about a shared plate axis of rotation. The angular resistance mechanism is connected between the first plate and the second plate. It increases angular resistance between the first plate and the second plate as an angle of rotation about the plate axis of rotation is increased. A shoe of an athlete contacts the first plate. The shoe is positioned on the first plate so that, as the athlete rotates a foot and the shoe enclosing the foot with respect to a part of the foot and about a foot axis of rotation, the foot axis of rotation and the plate axis of rotation coincide.

Abstract: It is the main object of this invention to provide a ubiquitous and multi-functional low power handheld mobile personal computing device which will function as a computing device the size of a PDA with large 17 inches or larger projection screen supporting various wireless local or WAN broadband communication links for data communication means such as Internet browsing, email access, file transfer, downloading, gaming, streaming, and VoIP applications. It will also function as a Portable Media Player for video and audio playback applications displaying a large, high resolution focus free and resizable projection image on any flat surface. Additionally it will function as a Mobile phone providing all of the voice communication functionalities of 3G and 4G mobile telephony systems.

Abstract: The scientist domain-centric user interface system may prompt the user to supply scientist-centric information expressed utilizing terminology of a scientific domain, such as biology or analytical chemistry. A translation system then generates control parameters to control the search algorithm, thus relieving the user from having to learn how select and configure the algorithm control parameters directly.

Abstract: Systems and methods for reducing background noise in a mass spectrum. The method includes the following steps of: (a) obtaining an original mass spectrum; (b) determining a noise mass spectrum corresponding to background noise in the original mass spectrum; and (c) determining a corrected mass spectrum by subtracting the noise mass spectrum from the original mass spectrum. Step (b) of the method may include the steps of: A) effecting a transformation of the original mass spectrum into the frequency domain to obtain an original frequency spectrum; B) identifying at least one dominant frequency in the original frequency spectrum; C) generating a noise frequency spectrum by selectively filtering for said dominant frequencies; and D) determining the noise mass spectrum by effecting a transformation of the noise frequency spectrum into the mass domain.

Abstract: The static MMS spectral reconstruction process is optimized using algorithmic methods. Because the static MMS encodes spectral information across the detector plane in a highly non-local way, optical errors have a non-local effect on the reconstruction which introduces noise and errors at regions throughout the spectral range. Mathematical signal processing techniques are used to condition and deconvolve the spectral image to compensate for non-ideal system behavior. Spectral signal-to-noise and accuracy are both improved, while the inherent resolution and etendue advantages of the static MMS technique are retained.