The famous polemics between I. P. Pavlov and K. S. Lashley in the pages of the "Psychological Review" in the thirties is discussed in this paper. The particular significance of this polemics for development of contemporary neuroscience is underlined, since the essentially novel concept of the brain activity mechanisms has been advanced and intelligence nature has been advanced on the basis of the synthesis of the two opposing theories, the localizationalism and equipotentialism.