Quiet debut for the double helix

Nature. 2003 Jan 23;421(6921):402-5. doi: 10.1038/nature01397.

Abstract

Past discoveries usually become aggrandized in retrospect, especially at jubilee celebrations, and the double helix is no exception. The historical record reveals a muted response by the scientific community to the proposal of this structure in 1953. Indeed, it was only when the outlines appeared of a mechanism for DNA's involvement in protein synthesis that the biochemical community began to take a serious interest in the structure.

Publication types

  • Historical Article
  • Portrait
  • Comment

MeSH terms

  • Biochemistry / history
  • DNA / chemistry
  • DNA / genetics
  • DNA / history*
  • DNA Replication
  • History, 20th Century
  • Models, Biological
  • Mutagenesis
  • Nucleic Acid Conformation*
  • Protein Biosynthesis
  • Proteins / chemistry
  • Proteins / genetics

Substances

  • Proteins
  • DNA