Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update

Sherif A Rezk; Xiaohui Zhao; Lawrence M Weiss

doi:10.1016/j.humpath.2018.05.020

Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update

Hum Pathol. 2018 Sep:79:18-41. doi: 10.1016/j.humpath.2018.05.020. Epub 2018 Jun 6.

Authors

Sherif A Rezk¹, Xiaohui Zhao², Lawrence M Weiss³

Affiliations

¹ Department of Pathology & Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, 92868, CA. Electronic address: srezk@uci.edu.
² Department of Pathology & Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, 92868, CA.
³ Department of Pathology & Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, 92868, CA; NeoGenomics Laboratories, Aliso Viejo, 92656, CA.

PMID: 29885408
DOI: 10.1016/j.humpath.2018.05.020

Abstract

Epstein-Barr virus (EBV) has been linked to many human neoplasms including hematopoietic, epithelial, and mesenchymal tumors. Since our original review of EBV-associated lymphoproliferative disorders in 2007, many advances and developments have been reported. In this review, we will examine the recent advances in EBV-associated lymphoid/histiocytic proliferations, dividing them into reactive, B cell, T/NK cell, immunodeficiency-related, and histiocytic/dendritic cell proliferations.

Keywords: B-cell lymphoproliferative disorders; Epstein-Barr virus; Immunodeficiency-related lymphoproliferative disorders; Reactive lymphoid proliferations; T-cell lymphoproliferative disorders.

Publication types

Review

MeSH terms

Cell Proliferation*
Epstein-Barr Virus Infections / pathology*
Epstein-Barr Virus Infections / virology
Herpesvirus 4, Human / pathogenicity*
Humans
Lymphoid Tissue / pathology*
Lymphoid Tissue / virology
Lymphoproliferative Disorders / pathology*
Lymphoproliferative Disorders / virology
Prognosis