Open Society Fund Prague (OSF-Prague) is a foundation supporting the development of spiritual values, humanistic aims, education, and culture in the Czech Republic. OSF-Prague cooperates with nongovernmental and nonprofit organizations, offers educational programs, contributes to the promotion of intellectual cooperation among Central and Eastern European countries, and supports other nonprofit activities.

The foundation has especially targeted issues raised by EU accession, particularly in areas such as the rule of law and corruption, civil society development, immigration and ethnic integration, human rights, and public health.