James MarshallJames A. Marshall

  • Thomas Jefferson Professor of Chemistry
  • B.S. University of Wisconsin (Madison), 1957
  • Ph.D. University of Michigan, 1960
  • N.I.H. Postdoctoral Fellow, Stanford University, 1960-1962
  • Arthur C. Cope Scholar Award, American Chemical Society, 2007
  • Centenary Medal and Lectureship of the Roal Society of Chemistry, 2007
  • Professor Associe at Joseph Fourier University in Grenoble France, 2008

CURRENT RESEARCH INTERESTS

Overview: In our research we identify natural products with interesting, often novel, structures and useful biological properties that may lead to medicinal agents for treatment of cancer, cardiovascular disorders and infectious diseases. We focus on key structural and stereochemical features present in these target natural products and devise mechanism or analogy based methodology for efficient construction of potentially useful subunits. Finally, we assemble the foregoing subunits by a combination of new and known reactions to synthesize the target substance and/or analogues thereof. Our overall program is thus target directed but methods driven.

Synthetic Targets of Current Interest in the Marshall Group

Recent Publications:

Synthesis of a C20-C26 Segment of Superstolide A by Addition of a Chiral Allenylzinc Reagent to (R)-N-Boc Alaninal. Marshall, J. A.; Mulhearn, J. J. Org. Lett. 2005, 7, 1593. [PDF]

Applications of Chiral Allenylzinc Additions and Noyori Asymmetric Reductions to an Enantioselective Synthesis of a C3-C13 Precursor of the Polyketide Phosphatase Inhibitor Cytostatin. Marshall, J. A.; Ellis, K. Tetrahedron Lett. 2004, 45, 1351. [PDF]

Diastereoselective Additions of Chiral Vinylzinc Reagents to α-Chiral Aldehydes. Marshall, J. A.; Eidam, P. Org. Lett. 2004, 6, 445. [PDF]

Directed Pd(0)-Catalyzed Hydrostannantion of Internal Alkynes. Marshall, J. A; Bourbeau, M. P. Tetrahedron Lett. 2003, 44, 1087. [PDF]

A Modular Synthesis of Annonaceous Acetogenins. Marshall, J. A.; Piettre, A.; Paige, M. A.; Valeriote, F. J. Org. Chem. 2003 1771. [PDF]

Total Synthesis and Structure Cofirmation of the Annonaceous Acetogenins 30(S)-Hydroxybullatacin, Uvarigrandin A, and Narumicin I. Marshall, J. A.; Piettre, A.; Paige, M. A.; Valeriote,J. Org. Chem. 2003, 1780. [PDF]

Total Synthesis of (-)- and (+)-Membrenone C. Marshall, J. A.; Ellis. Keith C. .Org. Lett. 2003, 5 1729. [PDF]

Synthesis of 2,5-Disubstituted Tetrahydrofurans by Stereospecific Elimination-Cyclization of 1-Iodomethyl-1,5-bis-epoxides. Marshall, J. A.; Chobanian, H. R. Org. Lett. 2003, 5, 1931. [PDF]

Additions of Chiral Allenylzinc Reagents to Acetaldehyde: Diastereomeric Cyclic Transition States with a Tetrahedral Zinc Atom Located by ab Initio and Density Functional Theory. Gung, B. W.; Xue, X.; Knatz, N.; Marshall. J. A. Organometallics, 2003, 22, 3158. [PDF]

Synthesis of Enantioenriched Propargylic Alcohols Related to Polyketide Natural Products. Marshalll,J. A.; Bourbeau, M. P. Org. Lett. 2003, 5, 3197. [PDF]

Total Synthesis and Structure Confirmation of Leptofuranin D. Marshall, J. A.; Schaaf, G. M. J. Org. Chem., 2003 68, 7428. [PDF]