Malaria and Giardia Drug Discovery
We are pursuing a rational drug design program that is guided by evaluation of structure-activity relationships (SAR) of a series of drug candidates ...
We are pursuing a rational drug design program that is guided by evaluation of structure-activity relationships (SAR) of a series of drug candidates ...
Dynamic Stereochemistry
The development of mechanistic insights into isomerization reactions and information about the conformational and configurational stability...
The development of mechanistic insights into isomerization reactions and information about the conformational and configurational stability...
Solid State Chemistry
Supramolecular self-assembly has become a widely recognized tool for the formation of well-defined noncovalent arrangements of organic building blocks...
Supramolecular self-assembly has become a widely recognized tool for the formation of well-defined noncovalent arrangements of organic building blocks...
Asymmetric Catalysis
Most biologically active compounds - flavors, nutrients, agrochemicals, pharmaceuticals - are chiral and more than 50 % of today's top selling drugs are single enantiomers ...
Most biologically active compounds - flavors, nutrients, agrochemicals, pharmaceuticals - are chiral and more than 50 % of today's top selling drugs are single enantiomers ...
Stereoselective Sensing of Chiral Compounds
We have developed highly constrained C2-symmetric diheteroarylnaphthalenes that undergo stereoselective interactions with a variety of chiral compounds, resulting...
We have developed highly constrained C2-symmetric diheteroarylnaphthalenes that undergo stereoselective interactions with a variety of chiral compounds, resulting...
Transition Metal Catalysis and Cross-Coupling Reactions
Recent efforts have provided highly active transition metal catalysts that allow one to replace aryl iodides...
Recent efforts have provided highly active transition metal catalysts that allow one to replace aryl iodides...
C. Wolf, Dynamic Stereochemistry of Chiral Compounds,
RSC Publishing, London, 2008
RSC Publishing, London, 2008
We thank NSF, NIH, ACS-PRF, and Combiphos Catalysts Inc. for financial support.