April 1, 2010
Associate Professor Timothy H. Warren
recently received new support from the National Science Foundation for his work that aims to unravel fundamental details of biological nitric oxide processing at copper ions. His proposal “HNO, NO, and RSNO Formation and Reactivity at Non-Heme Sites” was awarded a three-year, $432,500 grant by the Chemistry of Life Processes program.
Nitric oxide (NO) is a small molecule intricately coupled to a myriad of physiological responses such as the opening of blood vessels to enhance blood flow as well as anti-clotting activity. Despite the established importance of NO and RSNOs in biochemical signaling pathways as well as growing interest in HNO as a cardiac drug, enzymatic pathways for the generation and interconversion of these molecules connected to the biology of nitric oxide are not clearly delineated. A synthetic modeling approach will allow for the detailed examination of transformations among these various NO-derivatives promoted by copper ions in nitrogen-rich coordination environments related to those found in biology. The straightforward synthesis of copper complexes explored in this work will allow students with very limited synthetic experience, or none at all, such as first year undergraduate (or even high school) students, to contribute to the project.
page last updated: April 13, 2010
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