‘Clybourne Park,’ by Bruce Norris, at Walter Kerr Theater

“Is this safe?” the man asks, as he guardedly takes a seat on a packing crate in the first act of “Clybourne Park,” Bruce Norris’s sharp-witted, sharp-toothed comedy of American uneasiness. Oh, foolish mortal. Of course it isn’t safe. You’re about to start talking about (can I say the word?) race. You might as well be running blindfolded through a minefield.

It’s been more than two years since “Clybourne Park” was first staged in New York, Off Broadway at Playwrights Horizons. In the interim, a lot has happened both to this play — which opened Thursday night on Broadway in a superlative production at the Walter Kerr Theater — and this country. The play has picked up a Pulitzer Prize and traveled all over the place, including to London, where it won the Olivier Award.

As for this country, well just think of what it’s heard since the winter of 2010: the divisive shouting over the killing of the African-American youth Trayvon Martin; the horrified gasps over the charges that an American soldier massacred Afghan civilians; and the warm bath of applause that greeted the movie “The Help,” a sentimental story of black domestic workers and their employers in the South.

Though those events were all in the future when “Clybourne Park” was written, this play addresses them all, or at least what they stand for. Usually, when a work is as topical as this one is, it has a limited shelf life. Yet returning to “Clybourne Park” — which features its original excellent cast and sure-footed director, Pam MacKinnon — I realized that this play probably will be topical for many years to come. That’s bad news for America, but good news for theatergoers, as “Clybourne Park” proves itself more vital and relevant than ever on a big Broadway stage.

The very structure of “Clybourne Park” posits the idea of a nation (and even a world) trapped in a societal purgatory of ineptitude and anxiety. The play’s first act is set in a recently sold middle-class house in Chicago in 1959; the second act takes place in the same house (which has been recently resold) in 2009.

And by the way that house in Clybourne Park (still a segregated neighborhood in the late 1950s) is the very one that the Younger family was set to move into at the end of “A Raisin in the Sun,” Lorraine Hansberry’s watershed drama from 1959. In the two parts of “Clybourne Park” two other families are on the verge of moving. But Mr. Norris makes it stingingly clear that this is not the same as moving onward or upward.

That he efficiently dashes the cautious hopes raised by Hansberry in “Raisin” would seem to suggest that “Clybourne Park” is a downer. On the contrary, it’s far too funny and stimulating to be that.

Like the tamer comedies of Yasmina Reza (particularly “God of Carnage”) “Clybourne Park” provides the eternal and undeniable satisfactions of watching supposedly civilized people behaving like territorial savages. But Mr. Norris cuts deeper than Ms. Reza, and he’s not nearly as whimsical or as polite.

Black or white, male or female, every one of the characters in “Clybourne Park” is a jerk. (We can’t print what would be the real mot juste.) And I would argue that according to Mr. Norris being a jerk is the human condition. (Check out his earlier comedy, “The Pain and the Itch,” if you have any doubts.)

That’s because his people exist in a state of constant irritation with one another. They’re lonely, so they need the company. But whenever they’re together, they chafe. What’s more, they all speak different languages, even within a single family. Which means that whenever they try to say the right thing, it’s going to sound dead wrong to somebody else.

Both sections of “Clybourne Park” (each acted by the same seven-member ensemble) begin in states of suppressed tension. In the first act Bev and Russ (Christina Kirk and Frank Wood, superb as people warped in different ways by loneliness) are just days away from leaving the place they have lived for many years. (Their living room has been designed with anthropological detail by Daniel Ostling, and Ilona Somogyi created the period-exact costumes.) They’ve known tragedy in that home, and it’s time to get away.

They don’t know even know that it’s an African-American family, the (unseen) Youngers, to whom they’ve sold the place. But the officious Karl (Jeremy Shamos, portraying the only character also in “Raisin”), who lives in the area with his wife, Betsy (Annie Parisse), does, and he is determined to stop the sale. (Betsy is deaf, which means she hears about as accurately as anybody else in this play.)

This leads to the kind of verbal donnybrook in which people who dislike one another to begin with are saddled with a flammable subject. Jim, the sermonizing young minister (Brendan Griffin), extends the debate to include Francine (Crystal A. Dickinson), Bev’s African-American maid, and her husband, Albert (Damon Gupton).