Fluspirilene
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| Systematic (IUPAC) name | |
| 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ℞ Prescription only |
| Routes | IM |
| Identifiers | |
| CAS number | 1841-19-6 |
| ATC code | N05AG01 |
| PubChem | CID 3396 |
| IUPHAR ligand | 85 |
| DrugBank | DB04842 |
| ChemSpider | 3279  |
| UNII | C5QA4GLR9M |
| KEGG | D02629 |
| ChEMBL | CHEMBL46516 |
| Chemical data | |
| Formula | C29H31F2N3O |
| Mol. mass | 475.573 g/mol |
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Fluspirilene (Redeptin, Imap, R6218) is a diphenylbutylpiperidine antipsychotic drug, used for the treatment of schizophrenia.[1] It is administered intramuscularly.[2] It was discovered at Janssen Pharmaceutica in 1963.[3]
[edit] Chemistry
Fluspirilene can be synthesized starting from benzyl-piperidone and aniline.[3][4][5]
[edit] See also
[edit] References
- ^ van Epen JH (1970). "Experience with fluspirilene (R 6218), a long-acting neuroleptic". Psychiatr Neurol Neurochir 73 (4): 277–284. PMID 5478771.
- ^ Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Verbruggen FJ, van Nueten JM, Marsboom RH, Herin VV, Schaper WK (1970). "The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug". Arzneimittelforschung 20 (11): 1689–1698. PMID 4992598.
- ^ a b C. Janssen, NV Res. Lab., BE 633914 (1963)
- ^ P.A.J. Janssen, U.S. Patent 3,238,216 (1966)
- ^ P.A.J. Janssen, DE 1470125 (1963)
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