The more general meaning of khalifa refers to the successors of the prophet Muhammad.
British Dictionary definitions for Muhammad
Muhammad
/mʊˈhæməd/
noun
1.
?570–632 ad, the prophet believed by Muslims to be the channel for the final unfolding of God's revelation to mankind: popularly regarded as the founder of Islam. He began to teach in Mecca in 610 but persecution forced him to flee with his followers to Medina in 622. After several battles, he conquered Mecca (630), establishing the principles of Islam (embodied in the Koran) over all Arabia
1610s, Mohammed, Arabic masc. proper name, literally "the Praiseworthy," name of the prophet of Islam (c.570-632). The earliest forms of his name in English were Mahum, Mahimet (c.1200); originally also used confusedly for "an idol." Wyclif has Macamethe (c.1380), and Makomete also turns up in 14c. documents. Mahomet was common until 19c.; cf. Mohammed.
The Arab founder of Islam, Muhammad is held by Muslims to be the chief prophet of God. He was born in Mecca. Muslims believe that the Koran was dictated to him by an angel sent from God.