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It is shown that senescent fibroblasts and endothelial cells appear very early in response to a cutaneous wound, where they accelerate wound closure by inducing myofibroblast differentiation through the secretion of platelet-derived growth factor AA (PDGF-AA). Expand
It is concluded that unrepaired cytotoxic DNA damage induces a highly conserved metabolic response mediated by the IGF1/insulin pathway, which re-allocates resources from growth to somatic preservation and life extension, and demonstrates that ageing and end-of-life fitness are determined both by stochastic damage and genetics. Expand
The use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans is discussed. Expand
The results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.Expand
Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.Expand
The results indicate that the somatic mutation rate is almost two orders of magnitude higher than the germline mutation rate and that both mutation rates are significantly higher in mice than in humans. Expand
The ensemble approach may facilitate integration of multi-modal data linked to chronological age and sex that may lead to simple, minimally invasive, and affordable methods of tracking integrated biomarkers of aging in humans and performing cross-species feature importance analysis. Expand
It is shown that improvements in survival with age tend to decline after age 100, and that the age at death of the world’s oldest person has not increased since the 1990s, which strongly suggest that the maximum lifespan of humans is fixed and subject to natural constraints. Expand
Proceedings of the National Academy of Sciences…
The value of this transgenic mouse model in studying gene mutations in vivo is demonstrated and could be used as a sensitive, organ-specific, short-term mutagenicity assay in addition to its use in fundamental research. Expand
The results underscore the stochastic nature of the ageing process, and could provide a mechanism for age-related cellular degeneration and death in tissues of multicellular organisms.Expand
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