J. Vijg
Publications
417
h-index
70
Citations
17,980
Highly Influential Citations
481
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An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
M. Demaria, N. Ohtani, +11 authors J. Campisi
Biology, MedicineDevelopmental cell
22 December 2014
TLDR
It is shown that senescent fibroblasts and endothelial cells appear very early in response to a cutaneous wound, where they accelerate wound closure by inducing myofibroblast differentiation through the secretion of platelet-derived growth factor AA (PDGF-AA). Expand
830 Citations
35
PDF
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
L. Niedernhofer, G. Garinis, +15 authors J. Hoeijmakers
Biology, Medicine
Nature

21 December 2006
TLDR
It is concluded that unrepaired cytotoxic DNA damage induces a highly conserved metabolic response mediated by the IGF1/insulin pathway, which re-allocates resources from growth to somatic preservation and life extension, and demonstrates that ageing and end-of-life fitness are determined both by stochastic damage and genetics. Expand
612 Citations
33
PDF
Aging and Genome Maintenance: Lessons from the Mouse?
P. Hasty, J. Campisi, J. Hoeijmakers, H. van Steeg, J. Vijg
Biology, Medicine
Science

28 February 2003
TLDR
The use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans is discussed. Expand
559 Citations
19
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
V. Pérez, H. Van Remmen, A. Bokov, C. Epstein, J. Vijg, A. Richardson
Biology, Medicine
Aging cell

25 November 2008
TLDR
The results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.Expand
294 Citations
13
DNA damage and ageing: new-age ideas for an age-old problem
G. Garinis, G. V. D. Horst, J. Vijg, J. Hoeijmakers
Biology, MedicineNature Cell Biology
12 November 2008
TLDR
Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.Expand
324 Citations
12
PDF
Differences between germline and somatic mutation rates in humans and mice
B. Milholland, Xiao Dong, Lei Zhang, X. Hao, Y. Suh, J. Vijg
Biology, MedicineNature communications
9 May 2017
TLDR
The results indicate that the somatic mutation rate is almost two orders of magnitude higher than the germline mutation rate and that both mutation rates are significantly higher in mice than in humans. Expand
192 Citations
12
Deep biomarkers of human aging: Application of deep neural networks to biomarker development
E. Putin, Polina Mamoshina, +7 authors A. Zhavoronkov
Engineering, Medicine
Aging

1 May 2016
TLDR
The ensemble approach may facilitate integration of multi-modal data linked to chronological age and sex that may lead to simple, minimally invasive, and affordable methods of tracking integrated biomarkers of aging in humans and performing cross-species feature importance analysis. Expand
176 Citations
12
PDF
Evidence for a limit to human lifespan
Xiao Dong, B. Milholland, J. Vijg
Biology, Medicine
Nature

13 October 2016
TLDR
It is shown that improvements in survival with age tend to decline after age 100, and that the age at death of the world’s oldest person has not increased since the 1990s, which strongly suggest that the maximum lifespan of humans is fixed and subject to natural constraints. Expand
250 Citations
11
PDF
Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo.
J. Gossen, W. D. de Leeuw, +5 authors J. Vijg
Biology, Medicine
Proceedings of the National Academy of Sciences…
1 October 1989
TLDR
The value of this transgenic mouse model in studying gene mutations in vivo is demonstrated and could be used as a sensitive, organ-specific, short-term mutagenicity assay in addition to its use in fundamental research. Expand
463 Citations
10
Increased cell-to-cell variation in gene expression in ageing mouse heart
R. Bahar, C. Hartmann, +8 authors J. Vijg
Biology, Medicine
Nature

22 June 2006
TLDR
The results underscore the stochastic nature of the ageing process, and could provide a mechanism for age-related cellular degeneration and death in tissues of multicellular organisms.Expand
492 Citations
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