This work identified receptor-activated TRPC5 and TRPC6 (transient receptor potential canonical type 5 and 6) channels as antagonistic regulators of actin remodeling and cell motility in fibroblasts and kidney podocytes.
Biology Journal of the American Society of Nephrology : JASN
These discoveries dovetail with previously described regulation of actin dynamics by the Ca(2+)-activated phosphatase, calcineurin, and the emergence of Rho GTPases as critical regulators of podocyte function in health and disease.
Changes in intracellular free calcium ([Ca2+]i) in polarized eosinophils provide a basis for understanding the organization and local activity of cytoskeletal proteins thought to underlie the directed migration of many cells.
Biology Proceedings of the National Academy of Sciences of the United States of America
An important role for Ca2+ in mediating neuronal responses to Slit2 is demonstrated and a general mechanism for neuronal guidance is suggested, which is both necessary and sufficient for directing neuronal migration.
It is proposed that cell motility results from the collective behavior of multiple self-organizing waves, such as the ability of cells to flow around barriers and the intricate spatial organization of protrusion at the leading edge of a motile immune cell, the human neutrophil.
Filopodia that extend from neuronal growth cones sample the environment for extracellular guidance cues, but the signals they transmit to growth cones are unknown and rapid signals appear to serve both as autonomous regulators of filopodial movement and as frequency-coded signals integrated within the growth cone.
Biology Proceedings of the National Academy of Sciences
It is demonstrated that an extracellular Ca2+ influx is an essential component, together with PI3K and F-actin, of the positive-feedback cycle that maintains leading-edge structure and ruffling activity and that supports the chemoattracted response.