DOI:​10.1097/00000478-199210000-00006
Corpus ID: 25581934
Intermediate Filamentous Proteins in Adult Granulosa Cell Tumors: An Immunohistochemical Study of 25 Cases
C. Otis, J. L. Powell, +1 author M. Carcangiu
Published 1992
Biology, Medicine

The American Journal of Surgical Pathology
Adult granulosa cell tumors (AGCTs) are classified as sex cord-stromal tumors of the ovary. However, they may be confused with other primary ovarian neoplasms. Intermediate filaments, specifically… Expand
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Highly Influential Citations
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Background Citations
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Topics from this paper
Neoplasms
ovarian neoplasm
granulosa cell tumor
Formalin
Cytokeratin
Sex Cord-Stromal Tumor
Staining method
Epithelioma
Differential Diagnosis
Stromal Neoplasm
Classification
Embedding
Electrophoresis
chorioallantoic membrane
Confusion
Molecular Weight
Ovary
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Results indicate that RT-PCR of CK-20, because of its high sensitivity and specificity, is a potential biomarker for detecting metastases in blood and in micrometastases in lymph nodes of patients treated for granulosa cell tumors. Expand
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Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody.
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The immunohistochemical findings show that, analogous to their ovarian counterparts, most testicular sex cord-stromal tumors are immunoreactive with antiinhibin.Expand
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The results of this study strongly suggest that dysregulation of the Wnt/&bgr;-catenin pathway plays a fundamental role in the pathogenesis of ovarian MCST. Expand
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In diagnostically challenging cases, the data indicate that inhibin immunohistochemistry is a very useful adjunct because granulosa and sertoli-stromal tumors are positive whereas other potential mimickers have been negative thus far.Expand
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