DOI:​10.1681/ASN.2015020204
Corpus ID: 207259082
Quantitative Micro-Computed Tomography Imaging of Vascular Dysfunction in Progressive Kidney Diseases.
J. Ehling, J. Bábíčková, +7 authors P. Boor
Published 2016
Biology, Medicine

Journal of the American Society of Nephrology : JASN
Progressive kidney diseases and renal fibrosis are associated with endothelial injury and capillary rarefaction. However, our understanding of these processes has been hampered by the lack of tools… Expand
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X-Ray Computed Tomography
Kidney Diseases
Noninvasive
Ureteral obstruction
Renal fibrosis
Wounds and Injuries
Blood Volume
kidney injury
Microfil
Vascular Diseases
Diameter (qualifier value)
Hypoxia-Ischemia, Brain
Blood capillaries
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References
SHOWING 1-10 OF 59 REFERENCES
Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging.
Tsutomu Inoue, E. Kozawa, +8 authors Hiromichi Suzuki
Medicine
Journal of the American Society of Nephrology : JASN
2011
TLDR
Functional MRI techniques used to assess kidney fibrosis and hypoxia of the cortex in 142 patients with either diabetic nephropathy, CKD without diabetes, or acute kidney injury demonstrated that the T2* and ADC MRI values correlated with renal pathology. Expand
252 Citations
PDF
Three-dimensional microcomputed tomography of renal vasculature in rats.
A. García-Sanz, A. Rodríguez-Barbero, M. Bentley, E. Ritman, J. C. Romero
Biology, Medicine
Hypertension

1998
TLDR
In conclusion, micro-CT is a promising method to evaluate renal vascular architecture relative to physiological and pathological alterations. Expand
Fluorescence microangiography for quantitative assessment of peritubular capillary changes after AKI in mice.
R. Kramann, Mari Tanaka, B. Humphreys
Medicine
Journal of the American Society of Nephrology : JASN
2014
TLDR
A direct link between severity of acute injury and future loss of peritubular perfusion is emphasized, it is demonstrated that reduced capillary caliber is an unappreciated long-term consequence of AKI, and a new quantitative imaging tool is offered for understanding how AKI leads to future CKD in mouse models is offered.Expand
79 Citations
PDF
Microcomputed tomography of kidneys following chronic bile duct ligation.
M. C. Ortiz, A. García-Sanz, +5 authors L. Juncos
Medicine
Kidney international

2000
TLDR
The results indicate that after CBDL, there is a selective decrease in cortical vascular filling, which may contribute to the salt and water retention that accompanies cirrhosis. Expand
Morphologic and Dynamic Renal Imaging With Assessment of Glomerular Filtration Rate in a pcy-Mouse Model Using a Clinical 3.0 Tesla Scanner
M. Sadick, Daniel Schock, B. Kraenzlin, N. Gretz, S. Schoenberg, H. Michaely
MedicineInvestigative radiology
2009
TLDR
The aim was to determine the feasibility of morphologic and contrast-enhanced dynamic magnetic resonance imaging for GFR assessment in pcy (polycystic kidneys and fibrosis) mice, using a clinical 3.0 Tesla scanner.Expand
19 Citations
Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury.
M. Hörbelt, So-Young Lee, +4 authors T. A. Sutton
Medicine
American journal of physiology. Renal physiology
2007
TLDR
Findings indicate that the loss of endothelial cells following ischemic injury is not a major contributor to altered microvascular permeability, although renal microVascular endothelial Cells are vulnerable to the initiation of apoptotic mechanisms following isChemic injury that can ultimately impact microv vascular density. Expand
144 Citations
PDF
Micro-CT imaging of tumor angiogenesis: quantitative measures describing micromorphology and vascularization.
J. Ehling, B. Theek, +10 authors T. Lammers
Biology, Medicine
The American journal of pathology
2014
TLDR
It is considered that combining highly accurate functional with highly detailed anatomical μCT is a useful tool for facilitating high-throughput, quantitative, and translational (anti-) angiogenesis and antiangiogenesis research. Expand
Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy.
R. Chevalier, M. Forbes, B. Thornhill
Medicine
Kidney international

2009
TLDR
The UUO model is likely to reveal useful biomarkers of progression of renal disease, as well as new therapies, which are desperately needed to allow intervention before the establishment of irreversible renal injury. Expand
CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis
J. Ehling, M. Bartneck, +11 authors F. Tacke
Biology, Medicine
Gut

2014
TLDR
In vivo and anatomical ex vivo µCT analyses demonstrated that inhibition of monocyte infiltration by targeting the chemokine CCL2 prevented fibrosis-associated angiogenesis, but not fibrosis progression, and inflammatory monocyte-derived macrophages primarily fostered sproutingAngiogenesis within the portal vein tract. Expand
Renal endothelial dysfunction in acute kidney ischemia reperfusion injury.
D. Basile, M. Yoder
Medicine
Cardiovascular & hematological disorders drug targets
2014
TLDR
It is posited that the cause of the sustained impairment in kidney capillary density results from impaired endothelial growth responses and suggested that this limitation is a primary contributing feature underlying progression of chronic kidney disease.Expand
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