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Nalidixic Acid

Known as: Acido nalidixico, 1,8-Naphthyridine-3-carboxylic Acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-, Acide nalidixique 
A synthetic quinolone and antibacterial agent with urinary tract antiseptic activity. Nalidixic acid concentrates in the renal tubules and bladder… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (8)

7-carboxynalidixic acid7-hydroxynalidixic acidNevigramonPA 2789

Broader (3)

Anti-Bacterial AgentsNalidixateTopoisomerase II Inhibitors
Decreased Protein Synthesis [PE]Drug AllergyEscherichia coli InfectionsIn Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Challenges of Antibacterial Discovery
SUMMARY The discovery of novel small-molecule antibacterial drugs has been stalled for many years. The purpose of this review is… 
Review
2005
Review
2005
Antibiotic resistance in food lactic acid bacteria--a review.
Highly Cited
2003
Highly Cited
2003
Isolation and Molecular Characterization of Nalidixic Acid-Resistant Extraintestinal Pathogenic Escherichia coli from Retail Chicken Products
ABSTRACT Fluoroquinolone use in poultry production may select for resistant Escherichia coli that can be transmitted to humans… 
Highly Cited
2003
Highly Cited
2003
Antibiotic resistance of E. coli in sewage and sludge.
Review
2000
Review
2000
The fluoroquinolone antibacterials: past, present and future perspectives.
Highly Cited
1998
Highly Cited
1998
Quinolone resistance from a transferable plasmid
Highly Cited
1988
Highly Cited
1988
Fatty Acids, Antibiotic Resistance, and Deoxyribonucleic Acid Homology Groups of Bradyrhizobium japonicum
The fatty acid compositions and multiple antibiotic resistance patterns of 32 strains of Bradyrhizobium japonicum correlated with… 
Highly Cited
1984
Highly Cited
1984
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.
Highly Cited
1977
Highly Cited
1977
Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.
ATP-dependent DNA supercoiling catalyzed by Escherichia coli DNA gyrase was inhibited by oxolinic acid, a compound similar to but… 
Highly Cited
1977
Highly Cited
1977
Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.
A target protein for nalidixic and oxolinic acids in Escherichia coli, the nalA gene product (Pnal), was purified to homogeneity… 
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