Cell signalling

Part 1. An overview of signalling

An introduction to cellular signalling

Pathways are the key to signalling

A look at some of the history and techniques of cell signalling

Part 2. Components that comprise signalling pathways

Extracellular signals: hormones, cytokines and growth factors

Detection of extracellular signals: the role of receptors

Protein phosphorylation, kinases and phosphatases

Cyclic nucleotides, cyclases and G proteins

Inositol phosphate metabolism and roles of membrane lipids

Intracellular calcium ions: control of their concentrations and roles in signalling

Reactive oxygen species, reactive nitrogen species and redox signalling

Part 3. Selected examples of signalling pathways and events

Insulin and the signal transduction cascades it invokes

Perception of the environment

Signalling in development and for the regulation of gene expression

Life, death and apoptosis

Part 4. Final thoughts

Cell signalling: importance, complexity and the future